Highlights
- •The diagnosis of the progression phase of multiple sclerosis is still retrospective.
- •Identifying the progression as early as possible is crucial to maximize novel drug efficacy.
- •PROM scores could be useful for catching progressive disease onset early.
- •SF36 physical functioning was revealed to be an independent predictor of disease progression.
Abstract
Introduction
The diagnosis of the progression phase of Multiple Sclerosis (MS) is still retrospective
and based on the objectivation of clinical disability accumulation.
Objectives
To assess whether the Patient Reported Outcomes Measures (PROMs) scores predict the
occurrence of disease progression within three years of follow-up.
Methods
Observational prospective multicenter study. Stable Relapsing-Remitting MS (RRMS)
patients were enrolled. At enrollment, patients completed the following PROMs: Beck
Depression Inventory- II, The Treatment Satisfaction Questionnaire for Medications,
Medical Outcomes Study Short Form 36- Item (SF36), Fatigue Severity Scale. EDSS was
assessed at enrollment and three years later. The outcome measure was defined as the
occurrence of confirmed disability progression (CDP) within three years of follow-up.
Univariable and multivariable logistic regression models were performed to study the
association between the final score of each test and the outcome.
Results
SF36-Physical Functioning (SF36-PF) was the only independent variable associated with
the outcome. The ROC curve analysis determined a score of 77.5 at SF36-PF as the cut-off
point identifying patients experiencing CDP within three years of follow-up [AUC:
0.66 (95% CI: 0.56–0.75)].
Conclusions
RRMS patients scoring higher (>77.5) at SF36-PF subscale have a higher likelihood
to experience CDP within the next three years.
Keywords
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Article info
Publication history
Published online: April 28, 2023
Accepted:
April 24,
2023
Received in revised form:
March 18,
2023
Received:
January 13,
2023
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
