Abstract
Background
Women of fertile age who receive autologous hematopoietic stem cell transplantation
(AHSCT) due to multiple sclerosis (MS) are at risk of loss of ovarian function and
infertility because of the conditioning regimen with alkylating agents.
Objective
To present our data on fertility preservation by ovarian tissue cryopreservation (OTC)
in young women with MS before AHSCT.
Methods
Retrospective, observational cohort study
Results
Eight women had OTC. After AHSCT four had premature ovarian insufficiency (POI), and
two of these had autotransplantation of their cryopreserved ovarian tissue. Both women
regained ovarian function, and a spontaneous pregnancy was achieved resulting in the
delivery of a healthy baby.
Conclusion
OTC preserves fertility in young women with MS at risk of POI
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Multiple Sclerosis and Related DisordersAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Fertility in patients with multiple sclerosis: current knowledge and future perspectives.Neurol. Sci. 2006; 27: 231-239
- Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers.Fertil. Steril. 2021; 115: 1102-1115
- Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis.Hum. Reprod. Update. 2022; (Feb 24 [online ahead of print])
- Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort.Fertil. Steril. 2021; 116 (Oct): 1098-1106
- Cancer and fertility preservation: international recommendations from an expert meeting.BMC Med. 2016; 14https://doi.org/10.1186/s12916-015-0545-7
- Reproduction post-chemotherapy in young cancer patients.Mol. Cell. Endocrinol. 2000; 169: 123-131
- Long-term outcomes after autologous hematopoietic stem cell transplantation for multiple sclerosis.JAMA Neurol. 2017; 74: 459-469
- Ovarian function after transplantation of frozen, banked autologous ovarian tissue.N. Engl. J. Med. 2000; 342: 1919
- Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data.Fertil. Steril. 2022; 117: 181-192
- Cryopreservation of ovarian tissue for a decade in Denmark: a view of the technique.Reprod. Biomed. Online. 2011; 22: 162-171
- Autologous hematopoietic stem cell transplantation in the treatment of multiple sclerosis.Cold Spring Harb. Perspect. Med. 2019; 9: 1-15
- Pituitary-ovary axis and ovarian reserve in fertile women with multiple sclerosis: a pilot study.Mult. Scler. 2016; 22: 564-568
Article info
Publication history
Published online: April 11, 2023
Accepted:
April 10,
2023
Received in revised form:
October 12,
2022
Received:
April 27,
2022
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
