Highlights
- •RION patients may have antibodies to interfascicular cells of the optic nerve.
- •Binding sites of these antibodies co-localize with those of Sox2-antibody.
- •A subset of RION may be characterized with anti-glial antibodies.
Abstract
Background
Given the significance of glial cells in maintenance of neurons, antibodies directed
against glial cells of the optic nerve might reasonably be expected to have a pathogenic
impact in relapsing inflammatory optic neuropathy (RION).
Methods
We investigated IgG immunoreactive with the optic nerve tissue by indirect immunohistochemistry
using sera of 20 RION patients. Commercial Sox2-antibody was used for double immunolabeling.
Results
Serum IgG of 5 RION patients reacted with cells aligned in the interfascicular regions
of the optic nerve. IgG binding sites significantly co-localized with the Sox2-antibody.
Conclusion
Our results suggest that a subset of RION patients may harbor anti-glial antibodies.
Keywords
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References
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Article info
Publication history
Published online: March 31, 2023
Accepted:
March 30,
2023
Received:
February 25,
2023
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
