Correspondence| Volume 73, 104694, May 2023

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Serum IgG of patients with relapsing inflammatory optic neuropathy immunoreacts with Sox2-positive glial cells of the optic nerve


      • RION patients may have antibodies to interfascicular cells of the optic nerve.
      • Binding sites of these antibodies co-localize with those of Sox2-antibody.
      • A subset of RION may be characterized with anti-glial antibodies.



      Given the significance of glial cells in maintenance of neurons, antibodies directed against glial cells of the optic nerve might reasonably be expected to have a pathogenic impact in relapsing inflammatory optic neuropathy (RION).


      We investigated IgG immunoreactive with the optic nerve tissue by indirect immunohistochemistry using sera of 20 RION patients. Commercial Sox2-antibody was used for double immunolabeling.


      Serum IgG of 5 RION patients reacted with cells aligned in the interfascicular regions of the optic nerve. IgG binding sites significantly co-localized with the Sox2-antibody.


      Our results suggest that a subset of RION patients may harbor anti-glial antibodies.


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