Highlights
- •GSC is capable of decreasing oxidized DNA of RRMS patients.
- •GSC decreases inflammatory cytokines of RRMS patients.
- •GSC did not affect kidney and liver function of RRMS patients.
Abstract
Relapsing-remitting multiple sclerosis (RRMS) is the most common clinical course of
multiple sclerosis (MS), characterized by a chronic inflammatory state and elevated
levels of oxidative markers. Food supplements with potential anti-inflammatory, antioxidant
and neuroprotective effects have been tested as possible adjuvants in the treatment
of MS. In this sense, this pilot study was carried out with the aim of verifying whether
a minimum daily dose of a guarana, selenium and l-carnitine (GSC) based multi supplement, mixed in cappuccino-type coffee, administered
for 12 weeks to 28 patients with RRMS could differentially modulate oxidative blood
markers (lipoperoxidation, protein carbonylation and DNA oxidation) and inflammatory
blood markers (protein levels of cytokines IL-1β, IL-6, TNF-α, IFN-γ, IL-10, gene
expression of these cytokines, and NLRP3 and CASP-1 molecules, and C-reactive protein
levels). The results indicate that a low concentration of GSC is capable of decreasing
the plasma levels of oxidized DNA and pro-inflammatory cytokines of RRMS patients.
The results support further research into the action of GSC on clinical symptoms,
not only in patients with MS, but also with other neurological conditions.
Graphical abstract
Graphical Abstract
Keywords
Abbreviations:
Caspase-1 ((casp-1)), Enzyme-linked immunosorbent assay ((elisa)), Federal university of santa maria ((ufsm)), Glutamic oxaloacetic transaminase ((got)), Glutamic pyruvic transaminase ((gpt)), Guarana ((g)), Guarana (selenium, l-carnitine, (gsc)), Interferon gamma ((ifn-γ)), Interleukin-1 beta ((il-1β)), Interleukin-6 ((il-6)), Interleukin-10 ((il-10)), l-carnitine ((c)), Multiple sclerosis ((ms)), National Health Surveillance Agency ((ANVISA)), oxidized DNA ((oxDNA)), Pontifical Catholic University of Rio Grande do Sul ((PUCRS)), reactive oxygen species ((ROS)), real-time polymerase chain reaction ((RT-PCR)), relapsing-remitting multiple sclerosis ((RRMS)), selenium ((S))To read this article in full you will need to make a payment
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Article info
Publication history
Published online: January 13, 2023
Accepted:
January 12,
2023
Received in revised form:
December 22,
2022
Received:
August 24,
2022
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
