Abstract
Amplitude of low-frequency fluctuations (ALFF) is defined as changes of BOLD signal
during resting state (RS) brain activity. Previous studies identified differences
in RS activation between healthy and multiple sclerosis (MS) participants. However,
no research has investigated the relationship between ALFF and learning in MS. We
thus examine this here. Twenty-five MS and nineteen healthy participants performed
a paired-associate word learning task where participants were presented with extrinsic
or intrinsic performance feedback. Compared to healthy participants, MS participants
showed higher local brain activation in the right thalamus. We also observed a positive
correlation in the MS group between ALFF and extrinsic feedback within the left inferior
frontal gyrus, and within the left superior temporal gyrus in association with intrinsic
feedback. Healthy participants showed a positive correlation in the right fusiform
gyrus between ALFF and extrinsic feedback. Findings suggest that while MS participants
do not show a feedback learning impairment compared to the healthy participants, ALFF
differences might suggest a general maladaptive pattern of task unrelated thalamic
activation and adaptive activation in frontal and temporal regions. Results indicate
that ALFF can be successfully used at capturing pathophysiological changes in local
brain activation in MS in association with learning through feedback.
Keywords
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Article info
Publication history
Published online: January 06, 2023
Accepted:
January 5,
2023
Received in revised form:
December 6,
2022
Received:
July 14,
2022
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
