Highlights
- •The study demonstrated that plasma AIMP1 levels were dramatically elevated in patients with acute AQP4-IgG+ NMOSD than in HCs.
- •High-dose intravenous methylprednisolone therapy significantly reduced the levels of AIMP1 in patients with acute AQP4-IgG+ NMOSD.
- •Plasma AIMP1 levels in clinically remission NMOSD patients decreased but were still higher than in HCs.
- •The plasma AIMP1 levels positively correlated with EDSS scores and negatively correlated with serum C3 concentrations in patients with acute AQP4-IgG+ NMOSD.
Abstract
Background and objectives
Aminoacyl-tRNA synthetase complex interacting with multifunctional protein-1 (AIMP1)
has been reported to carry pro-inflammatory properties and anti-angiogenesis effects.
However, the exact role of AIMP1 in patients with NMOSD is not yet clear. Our objective
was to investigate the relationship between plasma AIMP1 levels and disease severity
in patients with AQP4-IgG+ NMOSD from North China based on the Expanded Disability Status Scale (EDSS) score.
Methods
Plasma AIMP1 levels were measured using ELISA kits in 94 patients with AQP4-IgG+NMOSD (48 in the acute phase before high-dose intravenous methylprednisolone (IVMP)
therapy, 21 in the acute phase after IVMP therapy, 25 in the clinical remission-phase)as
well as 33 healthy controls (HCs). The disability function of NMOSD patients was evaluated
using the EDSS score. Furthermore, the clinical characteristics of the patients were
also evaluated, and laboratory tests were performed on blood samples.
Results
The plasma AIMP1 levels in AQP4-IgG+NMOSD patients with acute phase before IVMP therapy were significantly higher as compared
to those in patients after the IVMP therapy (p < 0.001) as well as those in the clinical remission phase (p = 0.021) or HCs (p < 0.001). Plasma AIMP1 levels were positively correlated with EDSS scores (r = 0.485, p < 0.001) and negatively correlated with serum complement 3 concentrations (r =-0.452, p = 0.001). AIMP1 exhibited the potential to distinguish NMOSD from HCs (AUROC 0.820,
p < 0.0001) and could differentiate mild and moderate-severe NMOSD (AUROC 0.790, p = 0.0006). Furthermore, plasma AIMP1 levels of ≥49.55pg/mL were found to be an independent
predictor of the risk for moderate-severe NMOSD (with OR 0.03, 95%CI 0.001–0.654,
p = 0.026).
Conclusion
AIMP1 may be involved in the pathogenesis of AQP4-IgG+NMOSD disease and predict the disease activity, severity, or effect of treatment in
patients with NMOSD. Further studies should be performed to reveal the precise mechanisms
of AQP4-IgG+NMOSD.
Graphical abstract
Graphical Abstract
Keywords
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Article info
Publication history
Published online: January 03, 2023
Accepted:
January 2,
2023
Received in revised form:
October 18,
2022
Received:
July 20,
2022
Identification
Copyright
© 2023 Published by Elsevier B.V.
