Highlights
- •The scores of FSIQ, VIQ, PIQ, vocabulary, similarities, and digit-symbol in NMOSD and MS patients were lower than the control group.
- •There was no difference between NMOSD and MS groups in IQ scores, except in vocabulary and similarities subsets.
- •A greater EDSS score was associated with decreased scores of FSIQ, VIQ, and PIQ in NMOSD patients.
Abstract
Background
Cognitive impairment is common in people living with neuromyelitis optica spectrum
disease (NMOSD) and multiple sclerosis (MS). However, there is little published data
on intelligence quotient (IQ) in NMOSD patients. Therefore, we performed the present
study to compare IQ scores across NMOSD, MS, and control groups.
Method
In this cross-sectional study, 49 NMOSD (30 with positive aquaporin4 antibody), 41
MS, and 20 control individuals were recruited. The IQ score for each person was measured
using Wechsler Adult Intelligence Scale-Revised (WAIS-R). Participants were reported
on eleven scores of subsets, verbal IQ (VIQ), performance IQ (PIQ), and full score
IQ (FSIQ).
Result
The scores of FSIQ, VIQ, PIQ, vocabulary, similarities, and digit-symbol in NMOSD
and MS individuals were lower than the control group. Relative to control, NMOSD patients
reported a lower score of information. We found no difference between NMOSD and MS
groups, except in vocabulary and similarities. No significant difference between seropositive
and seronegative NMOSD groups was observed except for the information and block design.
In NMOSD group, a greater EDSS score was associated with decreased scores of FSIQ,
VIQ, and PIQ. Being employed and being married were associated with greater scores
of VIQ and PIQ, respectively. In both NMOSD and MS groups, advanced education was
associated with increased scores of FSIQ and VIQ.
Conclusion
Our study showed decreased IQ scores in NMOSD and MS. Further studies are required
to examine intellectual quotient in people with NMOSD and MS.
Keywords
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Article info
Publication history
Published online: December 28, 2022
Accepted:
December 27,
2022
Received in revised form:
December 5,
2022
Received:
September 4,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
