- •The volumes of the brains of MS patients were also decreased dramatically compare to the controls.
Background & objectives
MS is not only a demyelinating disease of central nervous system, but it also affects cortical and deep gray matter (GM). Furthermore, it causes axonal damage in the brain and spinal cord through inflammation and axonal degeneration. It is mostly seen between the ages of 20 and 40 and prevalence of the disease is higher among females than males. In the present study, we measured different parameters in the brains of patients with multiple sclerosis (MS) and healthy controls in both genders to determine the amount of brain atrophy quantitatively in MS patients.
We used T2-weighted MRI scans of 40 MS patients (25 females + 15 males) with clinically definite relapsing-remitting multiple sclerosis that was determined according to Poser criteria in multiple parts of the brain, and we compared these data with those of sex-matched healthy controls in the same numbers.
Wideness of the lateral and third ventricles and the volumes of cerebral sulci in MS patients were significantly increased compared to both male and female controls. Brain width, corpus callosum area and the total brain/cerebellum + brain stem volumes of MS patients were decreased considerably.
Interpretation & conclusions
The present measurements indicated that MS caused parenchymal destruction in the cortex, axonal degeneration and myelin loss in the white matter of the brain. Consequently, the current observations correlate well with worsening disability in MS patients.
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- Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis.J. Neuroimaging. 2005; 15: 30S-45S
- The correlation between ventricular diameter measured by transcranial sonography and clinical disability and cognitive dysfunction in patients with multiple sclerosis.Arch. Neurol. 2000; 57: 1289-1292
- Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis.Arch. Neurol. 2006; 63: 1301-1306
- Bicaudate ratio as a magnetic resonance imaging marker of brain atrophy in multiple sclerosis.Arch. Neurol. 2002; 59: 275-280
- Transcranial color-coded real-timesonography in the adult. 1: normal findings and cerebrovascular ischemia.Ultraschall Med. 1991; 12: 74-79
- How many people in the world have multiple sclerosis?.Neuroepidemiology. 1994; 13: 1-7
- Multiple sclerosis and corpus callosum atrophy: relationship of MRI findings to clinical data.Neuroradiology. 1988; 30: 478-480
- Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability.Arch. Neurol. 2001; 58: 65-70
- The prevalence of multiple sclerosis in the leeds health authority.J. Neurol. Neurosurg. Psychiatry. 1998; 64: 605-610
- Topographic distribution of plaques in the spinal cord in multiple sclerosis.Arch. Neurol. Psychiatry. 1950; 63: 382-414
- Human brain atlas-based multimodal MRI analysis of volumetry, diffusimetry, relaxometry and lesion distribution in multiple sclerosis patients and healthy adult controls: implications for understanding the pathogenesis of multiple sclerosis and consolidation of quantitative MRI results in MS.J. Neurol. Sci. 2012; 313: 99-109
- Estimation of Reference Volume Using the Cavalieri Method. Unbiased Stereology.1st edition. BIOS Scientific Publishers, Hong Kong, Taiwan, Singapore1998: 39-42
- Memory and learning disturbances in multiple sclerosis. MRI lesions and neuropsychological correlation.Eur. J. Radiol. 1991; 13: 220-224
- Determination of ventricular diameters in multiple sclerosis patients with transcranial sonography (TCS)—a two year follow-up study.J. Neurol. 2004; 251: 30-34
- Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).Neurology. 1983; 33 (Nov): 1444-1452
- Oxidative injury in multiple sclerosis cerebellar grey matter.Brain Res. 2016; 1642: 452-460
- The social epidemiology of multiple sclerosis.Sci. Total Environ. 1990; 90: 163-190
- Segmentation of multiple sclerosis lesions in brain MRI: a review of automated approaches.Inf. Sci. 2012; 186 (9): 164-185
- The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study.Acta Neurol. Scand. 2003; 108: 401-406
- Sensitivity and reproducibility of a new fast 3D segmentation technique for clinical MR-based brain volumetry in multiple sclerosis.Neuroradiology. 2004; 46: 906-915
- Progressive cerebral atrophy in multiple sclerosis. A serial MRI study.Brain. 1996; 119: 2009-2019
- The cervical cord in multiple sclerosis.Neuropathol. Appl. Neurobiol. 1978; 4: 151-162
- Brain atrophy of relapsing-remittig in multiple sclerosis relationship with “black holes”, disease duration and clinical disability.J. Neurol. Sci. 2000; 174: 85-91
- Functional brain reorganizatiom in multiple sclerosis: evidence from fMRI studies.J. Neuroimaging. 2006; 16: 104-114
- The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction.Neuroimage. 2005; 26: 1068-1077
- Diameter assessment of the third ventricle with transcranial sonography in patients with multiple sclerosis.J. Neuroimaging. 2010; 20: 53-57
- Regional gray matter atrophy in earl primary progressive multiple sclerosis.Arch. Neurol. 2006; 63: 1175-1180
- A longitudinal study of brain atrophy in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG).Neurology. 1999; 53: 139-148
- Prevalence survey of multiple sclerosis in the Australian Capital Territory.Intern. Med. J. 2001; 31: 161-167
- Acquired lesions of the corpus callosum: MR imaging.Eur. Radiol. 2006; 16: 905-914
- Clinical-magnetic resonance imaging correlations in multiple sclerosis.J. Neuroimaging. 2005; 15: 10S-21S
- Cortical atrophy, ventricular width in multiple sclerosis.Arch. Neurol. 2005; 63: 1301-1306
Published online: December 19, 2022
Accepted: December 18, 2022
Received in revised form: December 5, 2022
Received: January 20, 2022
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