Highlights
- •The volumes of the brains of MS patients were also decreased dramatically compare to the controls.
Abstract
Background & objectives
MS is not only a demyelinating disease of central nervous system, but it also affects
cortical and deep gray matter (GM). Furthermore, it causes axonal damage in the brain
and spinal cord through inflammation and axonal degeneration. It is mostly seen between
the ages of 20 and 40 and prevalence of the disease is higher among females than males.
In the present study, we measured different parameters in the brains of patients with
multiple sclerosis (MS) and healthy controls in both genders to determine the amount
of brain atrophy quantitatively in MS patients.
Methods
We used T2-weighted MRI scans of 40 MS patients (25 females + 15 males) with clinically
definite relapsing-remitting multiple sclerosis that was determined according to Poser
criteria in multiple parts of the brain, and we compared these data with those of
sex-matched healthy controls in the same numbers.
Results
Wideness of the lateral and third ventricles and the volumes of cerebral sulci in
MS patients were significantly increased compared to both male and female controls.
Brain width, corpus callosum area and the total brain/cerebellum + brain stem volumes
of MS patients were decreased considerably.
Interpretation & conclusions
The present measurements indicated that MS caused parenchymal destruction in the cortex,
axonal degeneration and myelin loss in the white matter of the brain. Consequently,
the current observations correlate well with worsening disability in MS patients.
Keywords
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Article info
Publication history
Published online: December 19, 2022
Accepted:
December 18,
2022
Received in revised form:
December 5,
2022
Received:
January 20,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
