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The biological rabbit hole: Only for the blind

Published:October 18, 2022DOI:https://doi.org/10.1016/j.msard.2022.104256
      In the Editors’ Welcome of June this year we highlighted the pivotal observation from Ascherio's group of a 26-32-fold elevated risk of MS in those with prior exposure to EBV within the previous 7.5 years (
      • Bjornevik K.
      • Cortese M.
      • Healy B.C.
      • Kuhle J.
      • Mina M.J.
      • Leng Y.
      • Elledge S.J.
      • Niebuhr D.W.
      • Scher A.I.
      • Munger K.L.
      • Ascherio A.
      Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.
      ). This represents the largest risk factor for MS ever described. Their evidence, combined with the fact that CD20 monoclonal antibodies are highly effective against MS, makes the case for Epstein Barr virus (EBV) infection as necessary, if not sufficient, to cause MS - or is it?
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