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Dramatic changes in multiple sclerosis incidence in Iran may be related to the “Will Rogers phenomenon”

Published:October 05, 2022DOI:https://doi.org/10.1016/j.msard.2022.104217
      In recent years, studies have shown that multiple sclerosis (MS) incidence has greatly increased in different geographical areas of Iran (
      • Pakdel M.
      • Hedstrom A.
      • Marufi N.
      • Hooshmand E.
      • Mohammadi A.A.
      • Marashi R.
      • Khosh Kholgh N.
      • Kazemi Moghaddam V.
      Dramatic changes in multiple sclerosis prevalence in Iran: a descriptive study in ten regions of Iran.
      ;
      • Hosseinzadeh A.
      • Sedighi B.
      • Kermanchi J.
      • Heidari M.
      • Haghdoost A.A.
      Is the sharp increasing trend of multiple sclerosis incidence real in Iran?.
      ). The increases in MS incidence in Iran are usually attributed to obesity and overweight childhood, cigarette and waterpipe smoking, vitamin D deficiency, urbanization, industrialization, and air pollution (
      • Amiri M.
      Multiple sclerosis in Iran: an epidemiological update with focus on air pollution debate.
      ;
      • Hosseinzadeh A.
      • Baneshi M.R.
      • Sedighi B.
      • Kermanchi J.
      • Haghdoost A.A.
      Geographic variations of multiple sclerosis in Iran: a population based study.
      ;
      • Asmarian N.
      • Sharafi Z.
      • Mousavi A.
      • Jacques R.
      • tamayo I.
      • Bind M.A.
      • Abutorabi-Zarchi M.
      • Moradian M.J.
      • Izadi S.
      Multiple sclerosis incidence rate in southern Iran: a bayesian epidemiological study.
      ). However, one of the most important factors that may be related to the increase of MS incidence in Iran and has been neglected is the “Will Rogers phenomenon".
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