- •This study investigated the count vs. volume measures of lesion activity in 176 RR PwMS over a 10-year period.
- •PwMS with confirmed disability progression (CDP) had greater cumulative new/enlarging T2-LV compared to stable PwMS.
- •PwMS with CDP did not differ from stable ones in new/enlarging T2 lesion count or total T2-LV.
- •PwMS with EDSS change >2.0 had significantly greater enlarging T2 lesion count (p = 0.01) and enlarging T2-LV (p = 0.038).
- •Enlargement of T2 lesions is more strongly associated with long-term disability progression compared to other conventional T2 lesion-based outcomes.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Multiple Sclerosis and Related Disorders
- Multiple sclerosis–the plaque and its pathogenesis.N. Engl. J. Med. 2006; 354: 942-955
- Revised diagnostic criteria of multiple sclerosis.Autoimmun. Rev. 2014; 13: 518-524
- Evolution of cortical and thalamus atrophy and disability progression in early relapsing-remitting MS during 5 years.AJNR Am. J. Neuroradiol. 2013; 34: 1931-1939
- A serial 10-year follow-up study of brain atrophy and disability progression in RRMS patients.Mult. Scler. 2016; 22: 1709-1718
- A Serial 10-Year Follow-Up Study of Atrophied Brain Lesion Volume and Disability Progression in Patients with Relapsing-Remitting MS.AJNR Am. J. Neuroradiol. 2019; 40: 446-452
- Brain atrophy and disability progression in multiple sclerosis patients: a 10-year follow-up study.J. Neurol. Neurosurg. Psychiatr. 2014; 85: 1109-1115
- MRI as an outcome in multiple sclerosis clinical trials.Neurology. 2009; 72: 705-711
- Relating relapse and T2 lesion changes to disability progression in multiple sclerosis: a systematic literature review and regression analysis.BMC Neurol. 2013; 13: 180
- MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS).Mult. Scler. 1999; 5: 283-286
Hackmack K.W., Martin; Wuerfel, Jens; Pfueller, Caspar F.; Bellmann-Strobl, Judith; Paul, Friedemann; Haynes, John-Dylan. Can we overcome the ‘clinico-radiological paradox’ in multiple sclerosis? Neurology 2012.
- Resolving the clinico-radiological paradox in multiple sclerosis.F1000Res. 2017; 6: 1828
- Slowly eroding lesions in multiple sclerosis.Mult. Scler. 2017; 23: 464-472
- Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging.Acta Neuropathol. 2017; 133: 25-42
- Patterning Chronic Active Demyelination in Slowly Expanding/Evolving White Matter MS Lesions.AJNR Am. J. Neuroradiol. 2020;
- Remyelination can be extensive in multiple sclerosis despite a long disease course.Neuropathol. Appl. Neurobiol. 2007; 33: 277-287
- Atrophied Brain Lesion Volume: a New Imaging Biomarker in Multiple Sclerosis.J. Neuroimaging. 2018; 28: 490-495
- Randomized study of interferon beta-1a, low-dose azathioprine, and low-dose corticosteroids in multiple sclerosis.Mult. Scler. 2009; 15: 965-976
- New diagnostic criteria for multiple sclerosis: guidelines for research protocols.Ann. Neurol. 1983; 13: 227-231
- Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).Neurology. 1983; 33: 1444-1452
- Improved optimization for the robust and accurate linear registration and motion correction of brain images.Neuroimage. 2002; 17: 825-841
- Improved longitudinal gray and white matter atrophy assessment via application of a 4-dimensional hidden Markov random field model.Neuroimage. 2014; 90: 207-217
- MRI lesions as a surrogate for relapses in multiple sclerosis: a meta-analysis of randomised trials.Lancet Neurol. 2013; 12: 669-676
- Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis.Neurology. 2022;
- Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients.Ann. Neurol. 1989; 25: 43-49
- Exploring individual multiple sclerosis lesion volume change over time: development of an algorithm for the analyses of longitudinal quantitative MRI measures.Neuroimage Clin. 2019; 21101623
- Disease activity free status: a new end point for a new era in multiple sclerosis clinical research?.JAMA Neurol. 2014; 71: 269-270
- Temporally consistent probabilistic detection of new multiple sclerosis lesions in brain MRI.IEEE Trans. Med. Imaging. 2013; 32: 1490-1503
- Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis.Brain. 2019; 142: 2787-2799
- Expansion of chronic lesions is linked to disease progression in relapsing-remitting multiple sclerosis patients.Mult. Scler. 2021; 27: 1533-1542
- Immunopathology of secondary-progressive multiple sclerosis.Ann. Neurol. 2001; 50: 646-657
- New concepts on progressive multiple sclerosis.Curr. Neurol. Neurosci. Rep. 2007; 7: 239-244
- MRI biomarkers of disease progression and conversion to secondary-progressive multiple sclerosis.Expert. Rev. Neurother. 2020; : 1-14