Highlights
- •Currently, few studies that have investigated the prevalence of MS in China based on the latest diagnostic criteria.
- •The case ascertainment procedures of case finding combined with face-to-face diagnosis by experts is more probable to improve the accuracy of this study.
- •Accurate estimates of the prevalence of multiple sclerosis can inform the rational allocation of public health resources.
Abstract
Background
Multiple sclerosis (MS) is rare in China, and the prevalence previously reported may
be biased. Currently, few studies that have investigated the prevalence of MS in China
based on the latest diagnostic criteria.
Methods
Through a population-based survey from August 8, 2021 to December 31, 2021, we calculated
the prevalence of multiple sclerosis in 18,676,605 residents of Guangzhou, China.
MS patients were identified through the health insurance system of the Guangzhou Health
Insurance Bureau, and we surveyed 17 large tertiary hospitals using a case-finding
approach. All MS patients were diagnosed according to the 2017 McDonald criteria.
Results
A total of 143 patients in the resident population of Guangzhou were diagnosed with
MS, with a crude prevalence of 0.77 per 100,000 (95% confidence interval (CI): 0.65-0.90),
and the prevalence was higher in in females (1.14/100,000) than in males (0.44/100,000).
The age-adjusted prevalence was 0.92 per 100,000 (95% CI: 0.77-1.10). The prevalence
peaked at the age of 25-29 years (2.86/100,000) for both males and females (1.44/100,000
and 4.42/100,000, respectively).
Conclusions
This is the first study to report the prevalence of MS in Guangzhou, China, according
to the criteria. Our study shows that the prevalence of MS in Guangzhou is lower than
that in other cities in China.
Keywords
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Article info
Publication history
Published online: August 27, 2022
Accepted:
August 26,
2022
Received in revised form:
August 23,
2022
Received:
May 25,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
