Highlights
- •Several connectivity were decreased in cognitively impaired patients with NMOSD.
- •Decreased connectivity were associated with worse cognitive performance.
- •Intranetwork connectivity in the pDMN were decreased in cognitively impaired patients.
- •Internetwork connectivity between SN and pDMN/rFPN were decreased in cognitively impaired patients.
Abstract
Background
Cognitive impairment is one of the common symptoms in patients with neuromyelitis
optica spectrum disorder (NMOSD). However, the underlying mechanism remains unclear.
Resting-state functional magnetic resonance imaging (rs-fMRI) offers the opportunity
to reveal the patterns of brain activity in patients with different cognitive states.
Accordingly, this study investigated functional connectivity (FC) abnormalities within
and between the main cognitive networks in cognitively impaired (CI) patients with
NMOSD and their correlations with cognitive performance.
Methods
Thirty-four patients with NMOSD and 39 healthy controls (HC) were included. Neuropsychological
evaluations and rs-fMRI scanning were performed. Patients were classified as CI (n = 16) or cognitively preserved (CP; n = 18) according to neuropsychological evaluations. Seven components representing
six main cognitive networks were selected by group independent component analysis.
The differences in inter- and intranetwork FC among CI, CP, and HC groups were assessed.
The correlation between FC values and neuropsychological data in NMOSD was calculated.
Results
The CI group showed decreased intranetwork connectivity in the posterior default mode
network (pDMN) compared with the HC group (P < 0.05, GRF corrected), and decreased internetwork connectivity between the salience
network (SN) and pDMN, and between the SN and right frontoparietal network (rFPN)
compared with CP and HC groups. The altered FC values were significantly correlated
with cognitive performance in the whole NMOSD group.
Conclusion
The disconnection within the pDMN and between the SN and pDMN or rFPN might suggest
the neural substrates underlying cognitive impairment in NMOSD.
Keywords
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Article info
Publication history
Published online: August 13, 2022
Accepted:
August 13,
2022
Received in revised form:
August 7,
2022
Received:
February 17,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
