Highlights
- •The mean erythrocyte zinc concentration was above the recommendations in the groups.
- •The mean values of plasma zinc and superoxide dismutase activity were higher in the multiple sclerosis group.
- •In both the case and control groups, the mean superoxide dismutase activity was above the recommended level.
- •Superoxide dismutase activity correlated inversely with the number of outbreaks.
Abstract
Background
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system.
Objective
To investigate plasma and erythrocyte zinc status and its relationship to MS.
Methods
Cross-sectional study, including 98 participants, distributed in groups: case (MS,
n = 49), diagnosed with MS and control (n = 49), matched by age and sex with the case group. Zinc was analyzed by flame atomic
absorption spectrophotometry, and superoxide dismutase (SOD) activity by spectrophotometry.
Results
Mean plasma zinc was 94.6 (22.1) μg/dL for MS patients and 81.5 (31.3) μg/dL for control
group, with statistical difference (p = 0.023). The mean erythrocyte zinc was 83.6 (41.6) µg/gHb for case group and 72.6
(31.5) µg/gHb for control. Erythrocyte SOD activity was above reference values, significantly
different for MS patients (p = 0.003). There was a significant direct correlation between erythrocyte zinc and
SOD (r = 0.835; p < 0.001). SOD showed inverse correlation with MS outbreaks (r = -0.317; p = 0.027).
Conclusion
Patients with MS have normal plasma and elevated erythrocyte zinc. Erythrocyte zinc
showed positive correlation with SOD, which correlated inversely to outbreaks.
Keywords
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Article info
Publication history
Published online: July 18, 2022
Accepted:
July 17,
2022
Received in revised form:
June 30,
2022
Received:
April 6,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
