Highlights
- •The mean psychosocial subscale scores difference between 2 groups was significant.
- •Differences in cognitive scores between groups were significant (p˂0.001).
- •The mean total score for MFIS was statistically significant between 2 groups.
- •lavender can be an effective intervention in reducing fatigue in RRMS patients.
- •The lavender's neuroprotective and antioxidant effects may explain the findings.
Abstract
Background
Fatigue is one of the most common complications of Multiple Sclerosis (MS) patients.
Several pharmacological and non-pharmacological interventions have been recommended
to control this complication. Lavender is one of the plants considered by Persian
Medicine (PM) and recommended by scholars of past centuries in the treatment of neurological
diseases. This study aimed to investigate the efficacy of lavender capsule on improving
fatigue symptoms in MS patients.
Material and methods
In a double-blind, controlled trial, using a computer block randomization approach,
48 confirmed MS patients with eligibility criteria of being 18 years or older, Modified
Fatigue Impact Scale (MFIS) ≥25, relapsing-remitting MS patients, EDSS ≤6, not pregnant,
not breastfeeding, and not suffering from other diseases that cause fatigue, were
randomized to receive capsules containing 600mg of lavender flowers as the intervention
group or capsules containing 600mg cornstarch as the control group. Patients were
randomized after completing the MFIS and were asked to take one capsule three times
daily for 60 days. The MFIS again checked to assess the impact of two interventions.
Analysis of Covariance (ANCOVA) was used to assess the impact of two interventions.
Results
24 patients included in each group. The mean (standard deviation) of MFIS was 40.56
(7.63) in the intervention and 41.43 (7.89) in the control groups (p=0.706) before
the intervention. However, there was a significant reduction (p0.001˂) in the intervention group, 7.04 (4.91) compared to the control group, 38.17
(9.78) after the intervention.
Conclusion
In comparison to cornstarch capsules, consuming the capsules of lavender flowers decreased
the MFIS in MS patients.
Keywords
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Article info
Publication history
Published online: June 25, 2022
Accepted:
June 24,
2022
Received in revised form:
June 4,
2022
Received:
February 2,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
