- •Fatigue is a disabling symptom commonly reported in relapsing-remitting multiple sclerosis (RRMS).
- •Previous evidence on the economic burden of fatigue in MS by fatigue status (low vs high) is limited.
- •This cross-sectional, retrospective, observational study of pooled data from the 2017 and 2019 US National Health and Wellness Survey evaluated the economic burden of fatigue.
- •Fatigue was positively and significantly associated with measures of economic burden.
- •RRMS poses a substantial economic burden on patients and society, particularly among those with high fatigue.
Abbreviations:CCI (Charlson Comorbidity Index), CHAMPUS (Civilian Health and Medical Program of the Uniformed Services), CI (confidence interval), ED (emergency department), GLM (generalized linear model), HCP (healthcare provider), HCRU (healthcare resource utilization), HF (high fatigue), LCL (lower confidence limit), LF (low fatigue), MFIS-5 (Modified Fatigue Impact Scale-5), MS (multiple sclerosis), NA (not applicable), NHWS (National Health and Wellness Survey), RRMS (relapsing-remitting multiple sclerosis), SD (standard deviation), SE (standard error), UCL (upper confidence limit), US (United States), VA (Veterans Affairs), WPAI (Work Productivity and Activity Impairment)
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