HIGHLIGHTS
- •MS progressively affects the central nervous system causing degeneration and disability.
- •Changes in miRNA expression relate to the diagnosis and prognosis of MS.
- •miRNAs are viable targets for MS treatment and are also linked to therapy success.
Abstract
Micro-RNAs (miRNAs) are noncoding, single stranded segments of RNA measuring 19 to
25 nucleotides in length. They play an active role in autoimmune diseases, including
multiple sclerosis (MS). These structures have been studied given their implication
in the process of diagnosis, disease development, treatment and prognosis of MS. Given
the progressive and neurodegenerative nature of MS, miRNAs have been identified as
critical mediators and molecular pinpoints of the disease, which poses them as excellent
candidates for the obtention of suitable biomarkers and treatment targets. This review
condenses recent findings on the role of miRNAs in multiple sclerosis, including their
role in MS etiology and molecular mechanisms of the disease, exploitation of miRNAs
as diagnostic tools and biomarkers, miRNAs as treatment option or target for MS, and
their significance as predictors of disease prognosis.
Keywords
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Article info
Publication history
Published online: April 30, 2022
Accepted:
April 27,
2022
Received in revised form:
April 22,
2022
Received:
November 24,
2021
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
