Highlights
- •Irisin serum levels increased significantly after aerobic exercise in RRMS patients.
- •Aerobic exercise improves depression, and fatigue in pwMS.
- •Aerobic exercise positively affects information processing and working memory in pwMS.
Abstract
Background
Multiple sclerosis (MS) is a chronic progressive neurodegenerative disease of the
central nervous system. Although there is increasing evidence that aerobic exercise
has a positive effect on both cognitive and psychological functioning, there is limited
evidence for Relapsing-Remitting MS (RRMS) patients. Moreover, it is unclear at what
exercise modality and intensity the irisin, the cleaved and circulating form of the
exercise-associated membrane protein Fibronectin Type III Domain Containing 5, is
induced in patients with MS. This study aimed to investigate the effect of a regular
aerobic exercise program on irisin serum level, depression, fatigue, and cognitive
performance in patients with MS.
Methods
Thirty-two individuals with RRMS were randomized into 2 groups as control and study
groups (mean EDSS score 1.69 and 1.97, respectively). While the Study Group received
a combined exercise training consisting of three sessions of aerobic exercise and
Frenkel Coordination Exercises per week for 6 weeks, the Control Group received only
Frenkel Coordination Exercise training. Before and after the study, the cognitive
performance of the participants were evaluated with the Paced Auditory Serial Addition
Test with 3-second stimulus (PASAT-3), their maximum aerobic capacity with the Fitmate
Pro® (VO2max), their fatigue status with the Fatigue Impact Scale (FIS), and their depression
status with the Beck Depression Inventory (BDI). Irisin serum levels were analyzed
with Enzyme-Linked ImmunoSorbent Assay (ELISA) test from the serum samples of individuals.
Results
Our results revealed that the irisin serum level significantly increased in the Study
Group. Significant improvement in aerobic capacity, PASAT-3, FIS, and BDI values was
observed in the Study Group compared to the Control Group. When the ΔIrisin, ΔVO2max, ΔFIS, and ΔBDI values between the groups were compared, a significant difference
was found in favor of the study group.
Conclusion
The aerobic exercise revealed significant changes in depression, fatigue and irisin
serum levels in MS patients. We think that this study, in which a significant increase
in irisin serum level, significant improvement in depression, cognitive performance
and fatigue states were obtained in the Study Group, will be a pioneering study for
the future studies aiming to investigate the effects of irisin serum level on these
symptoms in detail.
Key Words
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Article info
Publication history
Published online: March 16, 2022
Accepted:
March 11,
2022
Received in revised form:
February 24,
2022
Received:
November 18,
2021
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
