Abstract
Increased immunoglobulin G (IgG) antibodies and oligoclonal bands (OCB) are the most
characteristic features of multiple sclerosis (MS), a neuroinflammatory demyelinating
disease with neurodegeneration at chronic stages. OCB are shown to be associated with
disease activity and brain atrophy. Despite intensive research over the last several
decades, the antigen specificities of the IgG in MS have remained elusive. We present
evidence which supports that intrathecal IgG is not driven by antigen-stimulation,
therefore provide reasoning for failed MS antigen identification. Further, the presence
of co-deposition of IgG and activated complement products in MS lesions suggest that
the IgG effector functions may play a critical role in disease pathogenesis.
Graphical abstract
Graphical Abstract
Keywords
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Article info
Publication history
Published online: October 11, 2021
Accepted:
October 10,
2021
Received in revised form:
October 5,
2021
Received:
July 31,
2021
Identification
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© 2021 Elsevier B.V. All rights reserved.
