Highlight
- •We investigated the prevalence of RLS/WED and to define the disease characteristics in young patients with pediatric onset multiple sclerosis (POMS).
- •Our study demonstrated high prevalence of RLS/WED in young patients with POMS. Eleven patients (22%) had RLS/WED - mostly of moderate in severity (54.5%).
- •Mean EDSS score was significantly higher in POMS patients with RLS/WED than those without (p = 0.003).
- •No statistical difference was detected about attack number, radiological features and laboratory data of OCB, ferritin levels, CRP, neutrophil-to-lymphocyte ratio, and 25-OH vitamin D.
Abstract
Background
Restless legs syndrome/Willis-Ekbom disease (RLS/WED) was shown to have a high prevalence
among adults with multiple sclerosis (MS).
Objective
We aimed to investigate the prevalence of RLS/WED and to define the disease characteristics
in young patients with pediatric onset multiple sclerosis (POMS)
Method
50 patients with POMS were questioned for the presence of RLS/WED. The demographic,
clinical and laboratory data were compared between POMS patients with and without
RLS/WED, including the total number of clinical and/or radiological MS attacks, interval
between first two attacks, EDSS, number of the hyperintense and/or contrast-enhancing
lesions, localization of demyelinating lesions, IgG index in cerebrospinal fluid,
oligoclonal band, serum ferritin, C-reactive protein, ratio of neutrophil to lymphocyte
count, and 25‑hydroxy vitaminD.
Results
Eleven patients (22%) had RLS/WED - mostly of moderate in severity (54.5%). Mean EDSS
score was significantly higher in POMS patients with RLS/WED than those without (p = 0.003). The Ig G index was almost two times higher in POMS patients with RLS/WED,
but it failed to reach to the statistically significant level (p = 0.073).
Conclusion
Our study demonstrated high prevalence of RLS/WED in young patients with POMS. Higher
EDSS scores in patients with POMS and RLS/WED indicates disease-related factors in
the emergence of RLS/WED.
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Article info
Publication history
Published online: October 02, 2021
Accepted:
September 30,
2021
Received in revised form:
September 29,
2021
Received:
August 1,
2021
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
