- •We investigated the prevalence of RLS/WED and to define the disease characteristics in young patients with pediatric onset multiple sclerosis (POMS).
- •Our study demonstrated high prevalence of RLS/WED in young patients with POMS. Eleven patients (22%) had RLS/WED - mostly of moderate in severity (54.5%).
- •Mean EDSS score was significantly higher in POMS patients with RLS/WED than those without (p = 0.003).
- •No statistical difference was detected about attack number, radiological features and laboratory data of OCB, ferritin levels, CRP, neutrophil-to-lymphocyte ratio, and 25-OH vitamin D.
Restless legs syndrome/Willis-Ekbom disease (RLS/WED) was shown to have a high prevalence among adults with multiple sclerosis (MS).
We aimed to investigate the prevalence of RLS/WED and to define the disease characteristics in young patients with pediatric onset multiple sclerosis (POMS)
50 patients with POMS were questioned for the presence of RLS/WED. The demographic, clinical and laboratory data were compared between POMS patients with and without RLS/WED, including the total number of clinical and/or radiological MS attacks, interval between first two attacks, EDSS, number of the hyperintense and/or contrast-enhancing lesions, localization of demyelinating lesions, IgG index in cerebrospinal fluid, oligoclonal band, serum ferritin, C-reactive protein, ratio of neutrophil to lymphocyte count, and 25‑hydroxy vitaminD.
Eleven patients (22%) had RLS/WED - mostly of moderate in severity (54.5%). Mean EDSS score was significantly higher in POMS patients with RLS/WED than those without (p = 0.003). The Ig G index was almost two times higher in POMS patients with RLS/WED, but it failed to reach to the statistically significant level (p = 0.073).
Our study demonstrated high prevalence of RLS/WED in young patients with POMS. Higher EDSS scores in patients with POMS and RLS/WED indicates disease-related factors in the emergence of RLS/WED.
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Published online: October 02, 2021
Accepted: September 30, 2021
Received in revised form: September 29, 2021
Received: August 1, 2021
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