Highlights
- •The overall prevalence of MI was 1.7% among MS patients.
- •The pooled odds ratio estimate for MI was 1.4, indicating that MS increased the odds of MI by 41%.
- •This highlights the need for clinicians to be more careful in the face of an increased MI burden in PwMS.
ABSTRACT
Background
People with multiple sclerosis (PwMS) are suggested to have a higher death rate compared
to the overall population. Increased risk and incidence of cardiovascular diseases
is a possible contributing factor here, as these patients are suggested to be more
prone to early death due to myocardial infarction (MI).
Aim
This systematic review aims to describe the prevalence of MI among PwMS in comparison
to the non-MS population.
Method
We thoroughly searched for publications reporting the prevalence of MI among PwMS
in PubMed, Scopus, Embase, and Web of Science. We excluded studies focusing on the
following conditions: ischemic heart disease only, autopsy of PwMS, MS patients with
a previous history of cardiovascular diseases, and MS diagnosed after MI. Moreover,
we excluded reviews, editorials, and commentaries. We used the random effect model
to calculate the pooled prevalence.
Results
We included nineteen studies, comprising 44 to 66616 participants. The overall prevalence
of MI was 1.7% among PwMS. The pooled odds ratio estimate for MI was 1.41 in PwMS
compared to the MS-free population.
Conclusions
Results of this systematic review confirms the increased risk of MI among PwMS. Consequently,
cardiovascular diseases should be considered in the management of these patients.
Keywords
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Article info
Publication history
Published online: September 30, 2021
Accepted:
September 27,
2021
Received in revised form:
September 20,
2021
Received:
September 9,
2021
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
