Highlights
- •Tremor is a disabling condition in MS cases.
- •Deep brain stimulation is used for tremor treatment.
- •The results of this systematic review and meta-analysis show that deep brain stimulation was effective for MS related tremor.
Abstract
Objective
This systematic review and meta-analysis aims to evaluate efficacy of deep brain stimulation
(DBS) in treating MS-related tremor.
Methods
We systematically searched PubMed, Web of Science, Embase, Scopus, Google Scholar,
and gray literature using a search strategy including the MeSH and text words as (((Brain
Stimulations) OR (Deep Brain Stimulations) OR (Deep Brain Stimulations) OR (Deep Brain
Brain Stimulation) OR (Deep Electrical Stimulation of the Brain)) AND (Multiple Sclerosis
OR Sclerosis, Multiple) OR Sclerosis, Disseminated) OR Disseminated Sclerosis) OR
MS (Multiple Sclerosis)) OR Multiple Sclerosis, Acute Fulminating).
Results
The literature search revealed 1663 articles, 1027 of which remained after removing
duplicates. Seventeen articles, published between 1999-2018, were included for the
meta-analysis, including overall 168 patients. Follow-up time ranged between 6-62
months. The pooled frequency of tremor improvement among the enrolled patients was
73%, (95% CI:64-83%) (I2=84.1%, p<0.001). The pooled standardized mean difference (SMD) (after –before) was
-2.9, (95% CI:-4.8, -0.98) (I2=89.8%, p<0.001).
Conclusion
The results of this systematic review and meta-analysis demonstrate MS-related tremor
improvement after DBS.
Keywords
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Article info
Publication history
Published online: September 06, 2021
Accepted:
September 4,
2021
Received in revised form:
September 1,
2021
Received:
May 11,
2021
Identification
Copyright
© 2021 Published by Elsevier B.V.
