Highlights
- •To find the role of oxidative stress in relapsing-remitting multiple sclerosis (RRMS) in Kurdish population.
- •To detect some major defects in haematological profiles in the RRMS.
- •To explore the disturbance of immunological parameters in the RRMS.
- •The utilization of Cu+2 supplement could be used as an effective modality in RRMS patients.
Abstract
Background
Multiple sclerosis (MS), as a neurodegenerative disorder, exhibits inflammation and
oxidative stress hallmarks.
Objective
The research aims to know any disturbances in haematological parameters and antioxidant
system of relapsing-remitting multiple sclerosis (RRMS) patients in the Kurdish population.
Methods
A case-control research meeting following the McDonald criterion was conducted on
100 RRMS patients and 100 controls.
Results
Lipid peroxidation products of malondialdehyde (MDA), erythrocyte sedimentation rate
(ESR), and total leucocyte counts (TLCs) were increased significantly, but copper
(Cu+2) and superoxide dismutase (SOD) were decreased significantly while nitric oxide
metabolites (NOx) and lymphocyte were not changed significantly if compared with that
of controls.
Conclusion
Findings from our study revealed that some defects were detected in haematological
profiles in the Kurdish population and disturbance of immunological parameters. In
addition, the utilization of Cu+2 supplement as an effective modality for RRMS patients
may be beneficial.
Keywords
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Article info
Publication history
Published online: August 27, 2021
Accepted:
August 26,
2021
Received in revised form:
August 13,
2021
Received:
July 19,
2021
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
