Highlights
- •Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing inflammatory disease of central nervous system with severe disabling attack that predominantly affects the optic nerves and the spinal cord.
- •Diagnosis of NMOSD and cancer at the same time could be complicated for clinicians.
- •Cancers should be considered in parallel with Patients with NMOSD to improve paraneoplastic NMOSD management.
- •Based on this systematic research, the most reported malignancies were breast and genitourinary (especially ovary) in women; lung, genitourinary (especially prostate) and hematology in men respectively.
Abstract
NMOSD
is a disease shown to be highly associated with other diseases such as autoimmune
diseases. There are a few reports of this association with cancer. So, this systematic
review aimed to obtain a broad understanding on the cancers associated in NMOSD, including
the source of common perceptions and assumptions in this regard.
Methods
in this study, we systematically searched the PubMed, EMBASE, SCOPUS, Web of Sciences,
Proquest, Ovid, conference proceedings, and reference lists of the retrieved articles.
All NMOSD cases who met the last version of criteria for its diagnosis, which reported
the patients with a history of cancer before or after the onset of neurological symptoms
without time limitations, and those who were referred as paraneoplastic neuromyelitis
optica in articles published in English language (both the abstract & full text),
were assessed. Finally, each study was critically appraised.
Results
Only 47 studies met the inclusion criteria, so they were assessed for qualitative
synthesis.
Considering the Euro network criteria, only 62 cases met this issue. The mean age
of 52.21 ± 17.14 and 52.16 ± 17.21 was reported for cancer and NMOSD cases with female
predominance (79%), respectively. The most reported organ in the cancer population
were genitourinary (n = 14, 22.3%), breast (n = 12, 19.4%), lung (n = 12, 19.3%), gastrointestinal (n = 7, 11.3%), and hematology (n = 6, 9.7%), respectively.
Conclusion
In older NMOSD patients without suspicious symptoms, we recommend paying more attention
to lung, breast and genitourinary (especially ovary) cancer screening. Also, cancer
resection had positive effect on the attack numbers after receiving treatment and
NMOSD recovery.
Keywords
Abbreviations:
Ap (Area Postrema), APS (Area Poterma Syndrome), Achr (Acetyl-Choline Receptor antibody), AMPAR (α-Amino-3‑hydroxy‑5-Methyl-4-isoxazolePropionic Acid Receptor), Anti (CV2/CRMP-5), AQP4 (Aquaporin-4), CMJ (Cervicomedullary Junction), CNS (Central Nervous System), CSF (Cerebrospinal Fluid), GABA-B (Gamma-Amino-Butyric Acid-B), IgG (Immunoglobulin G), IVIG (Intravenous Immunoglobulin), IVMP (Intra Venus Methylprednisolone), LETM (Longitudinally Extensive Transverse Myelitis), mg/dl (milligrams per deciliter), μl (Microliter), MRI (Magnetic Resonance Imaging), NMDAR (Anti N-Methyl-D-Aspartate Receptor), NMO (Neuromyelitis Optica), NMOSD (Neuromyelitis Optica Spectrum Disorders), OCB (Oligo Clonal Bond), ON (Optic Neuritis), PLEX (Plasma Exchange), PNS (Paraneoplastic Neurologic Syndromes), PMN (Polymorphonuclear Leukocytes), TM (Transverse Myelitis), WBC (White Blood Cell)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: August 27, 2021
Accepted:
August 26,
2021
Received in revised form:
August 21,
2021
Received:
April 18,
2021
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
