Advertisement

The prevalence of cognitive impairment in patients with neuromyelitis optica spectrum disorders (NMOSD): A systematic review and meta-analysis

Published:January 15, 2021DOI:https://doi.org/10.1016/j.msard.2021.102757

      Highlights

      • Cognitive impairment is reported in patients with NMOSD.
      • Different studies reported wide range of cognitive impairment.
      • The pooled prevalence of cognitive impairment estimated as 44%.

      Abstract

      Objective

      To estimate pooled prevalence of cognitive impairment in neuromyelitis opticaspectrum disorders (NMOSD) cases.

      Methods

      We searched PubMed, Scopus, EMBASE, Web of Science, and google scholar. We also searched the gray literature including references of the included studies, and conference abstracts which were published up to 20th October 2020. The search strategy included the MeSH and text words as (((Cognitive Dysfunctions) OR Cognitive Impairment) OR Cognitive Declines) OR Mild Cognitive Impairment) OR Mental Deterioration) AND (Neuromyelitis Optica spectrum disorder OR NMOSD OR Devic syndrome OR Neuromyelitis Optica spectrum disorders).

      Results

      The literature search revealed 1830 articles, after deleting duplicates 1434 remained. For the meta-analysis, 25 studies were included. Totally, 761 NMOSD patients were evaluated and 329 patients had cognitive impairment. Mean age ranged from 34-53 years. The prevalence of cognitive impairment ranged from 3% to 75%.The pooled prevalence of cognitive impairment was 44%, 95%CI(35%-54%), (I2=89.1%, P<0.001) which shows a high statistical heterogeneity . By excluding the abstract of Jung et al which was published in 2009, we found that the pooled prevalence was 34% (95% CI:31-37%) (I2=0)

      Conclusion

      Cognitive impairment should be considered in NMOSD patients as its pooled prevalence is estimated as 44%.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Multiple Sclerosis and Related Disorders
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. Altunrende, B., Yabalak, A., Polat, E., Kocaslan, M., Topcular, B., Demir, A.G. Cognitive profile in neuromyelitis optica spectrum disorder. 2016.

        • Beekman J.
        • Keisler A.
        • Pedraza O.
        • Haramura M.
        • Gianella-Borradori A.
        • Katz E.
        • et al.
        Neuromyelitis optica spectrum disorder: patient experience and quality of life.
        Neurol.-Neuroimmunol. Neuroinflammation. 2019; 6: e580
        • Blanc F.
        • Noblet V.
        • Jung B.
        • Rousseau F.
        • Renard F.
        • Bourre B.
        • et al.
        White matter atrophy and cognitive dysfunctions in neuromyelitis optica.
        PLoS One. 2012; 7: e33878
        • Blanc F.
        • Zéphir H.
        • Lebrun C.
        • Labauge P.
        • Castelnovo G.
        • Fleury M.
        • et al.
        Cognitive functions in neuromyelitis optica.
        Arch. Neurol. 2008; 65: 84-88
        • Cabrera-Gómez J.A.
        • Quevedo-Sotolongo L.
        • Gonzalez-Quevedo A.
        • Lima S.
        • Real-Gonzalez Y.
        • Cristofol-Corominas M.
        • et al.
        Brain magnetic resonance imaging findings in relapsing neuromyelitis optica.
        Mult. Scler. J. 2007; 13: 186-192
        • Cacciaguerra L.
        • Riccitelli G.C.
        • Radaelli M.
        • Pagani E.
        • Rocca M.
        • Filippi M.
        Global and Regional Hippocampal Volumes Are Preserved in Neuromyelitis Optica and Do not Seem to Be Related to Cognitive Impairment (P1. 2-073).
        AAN Enterprises, 2019
        • Chanson J.B.
        • Zephir H.
        • Collongues N.
        • Outteryck O.
        • Blanc F.
        • Fleury M.
        • et al.
        Evaluation of health-related quality of life, fatigue and depression in neuromyelitis optica.
        Eur. J. Neurol. 2011; 18: 836-841
        • Chavarro V.S.
        • Bellmann-Strobl J.
        • Zimmermann H.G.
        • Scheel M.
        • Chien C.
        • Oertel F.C.
        • et al.
        Visual system damage and network maladaptation are associated with cognitive performance in neuromyelitis optica spectrum disorders.
        Mult. Scler. Relat. Disord. 2020; 45102406
        • Cotter J.
        • Trew F.
        • Colville S.
        • Lyle D.
        • Cranley D.
        • Cormack F.
        • et al.
        Screening for cognitive impairment among patients with neuromyelitis optica using touchscreen cognitive testing in routine clinical care.
        J. Neurol. 2019; 266: 2571-2572
        • Czarnecka D.
        • Oset M.
        • Karlińska I.
        • Stasiołek M.
        Cognitive impairment in NMOSD—more questions than answers.
        Brain Behav. 2020; : e01842
        • Ebadi Z.
        • Saeedi R.
        • Hashemi S.N.
        • Gheini M.R.
        • Sahraian M.A.
        • Moghadasi A.N.
        Evaluation of types of psychological disorders in patients with neuromyelitis optica spectrum disorder (NMOSD).
        Mult. Scler. Relat. Disord. 2020; 102128
        • Eizaguirre M.B.
        • Alonso R.
        • Vanotti S.
        • Garcea O.
        Cognitive impairment in neuromyelitis optica spectrum disorders: what do we know?.
        Mult. Scler. Relat. Disord. 2017; 18: 225-229
        • Fernandez Diaz E.
        • Diaz-Maroto I.
        • Fernandez Valiente M.
        • Gomez Hontanilla M.
        • Gracia Gil J.
        Cognitive impairment in neuromyelitis optica and multiple sclerosis.
        Mult. Scler. J. 2017;
        • Fujimori J.
        • Nakashima I.
        • Baba T.
        • Meguro Y.
        • Ogawa R.
        • Fujihara K.
        Cognitive impairment in neuromyelitis optica spectrum disorders: a comparison of the Wechsler Adult Intelligence Scale-III and the Wechsler Memory Scale Revised with the Rao Brief Repeatable Neuropsychological Battery.
        Eneurologicalsci. 2017; 9: 3-7
        • He D.
        • Chen X.
        • Zhao D.
        • Zhou H.
        Cognitive function, depression, fatigue, and activities of daily living in patients with neuromyelitis optica after acute relapse.
        Int. J. Neurosci. 2011; 121: 677-683
        • He D.
        • Wu Q.
        • Chen X.
        • Zhao D.
        • Gong Q.
        • Zhou H.
        Cognitive impairment and whole brain diffusion in patients with neuromyelitis optica after acute relapse.
        Brain Cogn. 2011; 77: 80-88
        • Hollinger K.R.
        • Franke C.
        • Arenivas A.
        • Woods S.R.
        • Mealy M.A.
        • Levy M.
        • et al.
        Cognition, mood, and purpose in life in neuromyelitis optica spectrum disorder.
        J. Neurol. Sci. 2016; 362: 85-90
        • Hyun J.W.
        • Park G.
        • Kwak K.
        • Jo H.J.
        • Joung A.
        • Kim J.H.
        • et al.
        Deep gray matter atrophy in neuromyelitis optica spectrum disorder and multiple sclerosis.
        Eur. J. Neurol. 2017; 24: 437-445
        • Jarius S.
        • Ruprecht K.
        • Wildemann B.
        • Kuempfel T.
        • Ringelstein M.
        • Geis C.
        • et al.
        Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: a multicentre study of 175 patients.
        J. Neuroinflammation. 2012; 9: 14
        • Jung B.
        • Longato N.
        • Kleitz C.
        • Bitonto L.
        • Cremel N.
        • Brice B.
        • et al.
        A longitudinal study of cognitive functions in patients with neuromyelitis optica.
        Mult. Scler. 2011; 17: S401-S4S2
        • Jung B.
        • Noblet V.
        • Longato N.
        • Kleitz C.
        • Cremel N.
        • Kremer S.
        • et al.
        Cerebral volume and cognitive functions in neuromyelitis optica.
        Multiple Sclerosis. SAGE PUBLICATIONS LTD 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, England2009
        • Kawahara Y.
        • Ikeda M.
        • Deguchi K.
        • Hishikawa N.
        • Kono S.
        • Omote Y.
        • et al.
        Cognitive and affective assessments of multiple sclerosis (MS) and neuromyelitis optica (NMO) patients utilizing computerized touch panel-type screening tests.
        Intern. Med. 2014; 53: 2281-2290
        • Kim S.-H.
        • Hyun J.-W.
        • Jeong I.H.
        • Joung A.
        • Jo H.-J.
        • Yu E.-S.
        • et al.
        Comparison of cognitive performance and mri-measured brain volume and cortical thickness between patients with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS): a preliminary report.
        Mult. Scler. J. 2015; 21
        • Kim S.-H.
        • Kwak K.
        • Jeong I.H.
        • Hyun J.-W.
        • Jo H.-J.
        • Joung A.
        • et al.
        Cognitive impairment differs between neuromyelitis optica spectrum disorder and multiple sclerosis.
        Mult. Scler. J. 2016; 22: 1850-1858
        • Kim S.-H.
        • Park E.Y.
        • Park B.
        • Hyun J.-W.
        • Park N.Y.
        • Joung A.
        • et al.
        Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder.
        Sci. Rep. 2017; 7: 1-8
        • Leung S.
        • Chan K.
        Cognitive impairment of Chinese patients with multiple sclerosis and neuromyelitis optica.
        in: ECTRIMS 2016 & 21st Annual Conference of Rehabilitation. 2016
        • Li Y.
        • Xie P.
        • Lv F.
        • Mu J.
        • Li Q.
        • Yang Q.
        • et al.
        Brain magnetic resonance imaging abnormalities in neuromyelitis optica.
        Acta Neurol. Scand. 2008; 118: 218-225
        • Liu Y.
        • Fu Y.
        • Schoonheim M.M.
        • Zhang N.
        • Fan M.
        • Su L.
        • et al.
        Structural MRI substrates of cognitive impairment in neuromyelitis optica.
        Neurology. 2015; 85: 1491-1499
        • Matthews L.
        • Marasco R.
        • Jenkinson M.
        • Küker W.
        • Luppe S.
        • Leite M.I.
        • et al.
        Distinction of seropositive NMO spectrum disorder and MS brain lesion distribution.
        Neurology. 2013; 80: 1330-1337
        • Meng H.
        • Xu J.
        • Pan C.
        • Cheng J.
        • Hu Y.
        • Hong Y.
        • et al.
        Cognitive dysfunction in adult patients with neuromyelitis optica: a systematic review and meta-analysis.
        J. Neurol. 2017; 264: 1549-1558
        • Mirmosayyeb O.
        • Vaheb S.
        • Barzegar M.
        • Shaygannejad V.
        • Bonavita S.
        • Ghajarzadeh M.
        Screening neuromyelitis optica patients for COVID-19 infection.
        Autoimmun. Rev. 2020;
        • Modesti P.A.
        • Reboldi G.
        • Cappuccio F.P.
        • Agyemang C.
        • Remuzzi G.
        • Rapi S.
        • et al.
        Panethnic differences in blood pressure in Europe: a systematic review and meta-analysis.
        PLoS One. 2016; 11e0147601
        • Moore P.
        • Methley A.
        • Pollard C.
        • Mutch K.
        • Hamid S.
        • Elsone L.
        • et al.
        Cognitive and psychiatric comorbidities in neuromyelitis optica.
        J. Neurol. Sci. 2016; 360: 4-9
        • Moore P.
        • Methley A.
        • Pollard C.
        • Mutch K.
        • Jacob A.
        Neuropsychiatric features of neuromyelitis optica.
        Mult. Scler. J. 2014;
      2. Orviz Garcia, A., Valles Salgado, M., Matias-Guiu Antem, J., Gonzalez-Suarez, I., Oreja-Guevara, C.. Is cognitive impairment common in neuromyelitis optica spectrum disorders (NMOSD)? 2016.

        • Pache F.
        • Zimmermann H.
        • Finke C.
        • Lacheta A.
        • Papazoglou S.
        • Kuchling J.
        • et al.
        Brain parenchymal damage in neuromyelitis optica spectrum disorder–a multimodal MRI study.
        Eur. Radiol. 2016; 26: 4413-4422
        • Pittock S.J.
        • Weinshenker B.G.
        • Lucchinetti C.F.
        • Wingerchuk D.M.
        • Corboy J.R.
        • Lennon V.A.
        Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression.
        Arch. Neurol. 2006; 63: 964-968
        • Saji E.
        • Arakawa M.
        • Yanagawa K.
        • Toyoshima Y.
        • Yokoseki A.
        • Okamoto K.
        • et al.
        Cognitive impairment and cortical degeneration in neuromyelitis optica.
        Ann. Neurol. 2013; 73: 65-76
        • Saji E.
        • Yanagawa K.
        • Toyoshima Y.
        • Arakawa M.
        • Yokoseki A.
        • Nishizawa M.
        • et al.
        Characteristic features of cognitive dysfunction in neuromyelitis optica.
        Mult. Scler. J. 2011;
        • Salama S.
        • Marouf H.
        • Reda M.I.
        • Mansour A.R.
        • ELKholy O.
        • Levy M.
        Cognitive functions in Egyptian neuromyelitis optica spectrum disorder.
        Clin. Neurol. Neurosurg. 2020; 189105621
        • Vanotti S.
        • Cores E.V.
        • Eizaguirre B.
        • Melamud L.
        • Rey R.
        • Villa A.
        Cognitive performance of neuromyelitis optica patients: comparison with multiple sclerosis.
        Arq. Neuropsiquiatr. 2013; 71: 357-361
        • Vanotti S.
        • Eizaguirre B.
        • Cores E.
        • Melamud L.
        • Santos J.
        • Garcea O.
        • et al.
        Towards the Search for a Cognitive Pattern in Neuromyelitis Optica and Its Impact in Quality of Life (P02. 039).
        AAN Enterprises, 2012
        • Wang F.
        • Liu Y.
        • Li J.
        • Sondag M.
        • Law M.
        • Zee C.-S.
        • et al.
        Abnormal brain function in neuromyelitis optica: a fMRI investigation of mPASAT.
        Eur. J. Radiol. 2017; 95: 197-201
        • Zhang N.
        • Li Y.
        • Fu Y.
        • Shao J.
        • Luo L.
        • Yang L.
        • et al.
        Cognitive impairment in Chinese neuromyelitis optica.
        Mult. Scler. J. 2015; 21: 1839-1846