Abstract
Up to a third of patients with radiologically isolated syndrome (RIS) exhibit lower-than-expected
cognitive performances in neuropsychological evaluations, but the relationship between
cognitive impairment (CI) and quantitative magnetic resonance (MRI) measures has not
been stablished. Furthermore, the prognostic role of CI in RIS for conversion to MS
is currently unknown. We assessed 17 patients with RIS and 17 matched healthy controls
(HC) with a neurophychological battery and a 3T MRI. Six patients (35,3%) fulfilled
our criterion for CI (scores 2 SDs below the mean of HC in at least two cognitive
tests) (ci-RIS). The ci-RIS subgroup showed lower values of normalized brain and gray
matter volumes when compared to HC. After a median follow-up time of 4.5 years, the
ci-RIS subgroup presented a higher conversion rate to MS, suggesting that CI might
be an independent risk factor for conversion to MS.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Multiple Sclerosis and Related DisordersAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Association of MRI metrics and cognitive impairment in radiologically isolated syndromes.Neurology. 2012; 78: 309-314https://doi.org/10.1212/WNL.0b013e31824528c9
- Improving the characterization of radiologically isolated syndrome suggestive of multiple sclerosis.PLoS One. 2011; 6: e19452https://doi.org/10.1371/journal.pone.0019452
- Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study.Brain. 2018; 141: 2605-2618https://doi.org/10.1093/brain/awy202
- A comparison study of cognitive deficits in radiologically and clinically isolated syndromes.Mult. Scler. 2016; 22: 250-253https://doi.org/10.1177/1352458515591072
- Gray matter involvement in radiologically isolated syndrome.Medicine (Baltimore). 2016; 95: e3208https://doi.org/10.1097/MD.0000000000003208
- Cognitive function in radiologically isolated syndrome.Mult. Scler. 2010; 16: 919-925https://doi.org/10.1177/1352458510375707
- Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome.Neurology. 2009; 72: 800-805https://doi.org/10.1212/01.wnl.0000335764.14513.1a
- Radiologically isolated syndrome: 5-year risk for an initial clinical event.PLoS One. 2014; 9: e90509https://doi.org/10.1371/journal.pone.0090509
- Gray matter trophism, cognitive impairment, and depression in patients with multiple sclerosis.Mult. Scler. 2017; 23: 1864-1874https://doi.org/10.1177/1352458517692886
- Brain atrophy in radiologically isolated syndromes.J. Neuroimaging. 2015; 25: 68-71https://doi.org/10.1111/jon.12182
Article info
Publication history
Published online: January 11, 2021
Accepted:
January 8,
2021
Received in revised form:
January 2,
2021
Received:
November 27,
2020
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
