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Predicting conversion to multiple sclerosis by assessing cognitive impairment in radiologically isolated syndrome

  • Author Footnotes
    1 Department of Neurology, Hospital “La Mancha Centro”, Av. Constitución, 3, 13600 Alcázar de San Juan, Ciudad Real, Spain.
    ,
    Author Footnotes
    # Present address:The following authors have moved to a new institution since completing the research:
    Ángela Domingo-Santos
    Correspondence
    Corresponding author at: Av. Constitución 3, 13600 Alcázar de San Juan, Ciudad Real, Spain
    Footnotes
    1 Department of Neurology, Hospital “La Mancha Centro”, Av. Constitución, 3, 13600 Alcázar de San Juan, Ciudad Real, Spain.
    # Present address:
    # The following authors have moved to a new institution since completing the research:
    Affiliations
    Department of Neurology, University Hospital “12 de Octubre”, Av. de Córdoba, s/n, 28041 Madrid, Spain

    Foundation for Biomedical Research of “Hospital 12 de Octubre” (FIBH12O), Av. de Córdoba, s/n, 28041 Madrid, Spain
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  • Andrés Labiano-Fontcuberta
    Affiliations
    Department of Neurology, University Hospital “12 de Octubre”, Av. de Córdoba, s/n, 28041 Madrid, Spain
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  • Yolanda Aladro-Benito
    Affiliations
    Department of Neurology,University Hospital of Getafe, Carr. Madrid - Toledo, Km 12,500, 28905Getafe, Madrid, Spain
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  • M Luisa Martínez-Ginés
    Affiliations
    Department of Neurology, University Hospital “12 de Octubre”, Av. de Córdoba, s/n, 28041 Madrid, Spain

    Department of Neurology, University Hospital “Gregorio Marañón”, C/ del Dr. Esquerdo, 46, 28007 Madrid, Spain
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  • Lucía Ayuso-Peralta
    Affiliations
    Department of Neurology, University Hospital “Príncipe de Asturias”, Carr. deAlcalá, s/n, 28805 Meco, Madrid, Spain
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  • Verónica Puertas-Martín
    Affiliations
    Department of Neurology, University Hospital “12 de Octubre”, Av. de Córdoba, s/n, 28041 Madrid, Spain

    Foundation for Biomedical Research of “Hospital 12 de Octubre” (FIBH12O), Av. de Córdoba, s/n, 28041 Madrid, Spain

    International University of La Rioja (UNIR), Av. de la Paz, 137, 26006Logroño, La Rioja, Spain
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  • Marta Cerezo-García
    Affiliations
    Department of Neurology,University Hospital of Getafe, Carr. Madrid - Toledo, Km 12,500, 28905Getafe, Madrid, Spain

    International University of La Rioja (UNIR), Av. de la Paz, 137, 26006Logroño, La Rioja, Spain

    Complutense University of Madrid, Av. Séneca, 2, 28040 Madrid, Spain
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  • Yolanda Higueras-Hernández
    Affiliations
    Complutense University of Madrid, Av. Séneca, 2, 28040 Madrid, Spain

    GregorioMarañón Health Research Institute (IiSGM), C/ O'Donnell, 48, 28009 Madrid, Spain
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  • Author Footnotes
    2 Department of Computer Science and Information Technologies, Faculty of Computer Science, ISLA group, University of A Coruña, A Coruña, Spain.
    ,
    Author Footnotes
    # Present address:The following authors have moved to a new institution since completing the research:
    Virginia Mato-Abad
    Footnotes
    2 Department of Computer Science and Information Technologies, Faculty of Computer Science, ISLA group, University of A Coruña, A Coruña, Spain.
    # Present address:
    # The following authors have moved to a new institution since completing the research:
    Affiliations
    Neuroimaging Laboratory, Center for Biomedical Technology, Rey Juan Carlos University, C/ Tulipán, s/n, 28933Móstoles, Madrid, Spain
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  • Juan Álvarez-Linera
    Affiliations
    Department of Radiology, Ruber International Hospital,C/ de la Masó, 38, 28034 Madrid, Spain
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  • Author Footnotes
    # Present address:The following authors have moved to a new institution since completing the research:
    ,
    Author Footnotes
    3 Radiology and Nuclear Medicine Department.Erasmus MC. Rotterdam.The Netherlands & Imaging Physics Department. TU Delft. Delft. The Netherlands.
    Juan Antonio Hernández-Tamames
    Footnotes
    # Present address:
    # The following authors have moved to a new institution since completing the research:
    3 Radiology and Nuclear Medicine Department.Erasmus MC. Rotterdam.The Netherlands & Imaging Physics Department. TU Delft. Delft. The Netherlands.
    Affiliations
    Neuroimaging Laboratory, Center for Biomedical Technology, Rey Juan Carlos University, C/ Tulipán, s/n, 28933Móstoles, Madrid, Spain
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  • Julián Benito-León
    Affiliations
    Department of Neurology, University Hospital “12 de Octubre”, Av. de Córdoba, s/n, 28041 Madrid, Spain

    Centro de InvestigaciónBiomédicaen Red sobreEnfermedadesNeurodegenerativas (CIBERNED), C/ Valderrebollo, 5, 28031 Madrid, Spain

    Department of Medicine, Complutense University of Madrid, Av. Séneca, 2, 28040 Madrid, Spain
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  • Author Footnotes
    1 Department of Neurology, Hospital “La Mancha Centro”, Av. Constitución, 3, 13600 Alcázar de San Juan, Ciudad Real, Spain.
    # Present address:The following authors have moved to a new institution since completing the research:
    2 Department of Computer Science and Information Technologies, Faculty of Computer Science, ISLA group, University of A Coruña, A Coruña, Spain.
    3 Radiology and Nuclear Medicine Department.Erasmus MC. Rotterdam.The Netherlands & Imaging Physics Department. TU Delft. Delft. The Netherlands.
Published:January 11, 2021DOI:https://doi.org/10.1016/j.msard.2021.102749

      Abstract

      Up to a third of patients with radiologically isolated syndrome (RIS) exhibit lower-than-expected cognitive performances in neuropsychological evaluations, but the relationship between cognitive impairment (CI) and quantitative magnetic resonance (MRI) measures has not been stablished. Furthermore, the prognostic role of CI in RIS for conversion to MS is currently unknown. We assessed 17 patients with RIS and 17 matched healthy controls (HC) with a neurophychological battery and a 3T MRI. Six patients (35,3%) fulfilled our criterion for CI (scores 2 SDs below the mean of HC in at least two cognitive tests) (ci-RIS). The ci-RIS subgroup showed lower values of normalized brain and gray matter volumes when compared to HC. After a median follow-up time of 4.5 years, the ci-RIS subgroup presented a higher conversion rate to MS, suggesting that CI might be an independent risk factor for conversion to MS.

      Keywords

      Abbreviations:CI (cognitive impairment), ci-RIS (cognitively impaired radiologically isolated syndrome), cp-RIS (cognitively preserved radiologically isolated syndrome), CT (cortical thickness), D-FIS (Fatigue Impact Scale for Daily Use), EQ-5D (EuroQol 5-Dimensions), EQ-VAS (EuroQol Visual Analog Scale), GM (gray matter), HC (healthy controls), HDRS (Hamilton Depression Rating Scale), MRI (magnetic resonance imaging), MS (multiple sclerosis), NBV (normalized brain volume), NCV (normalized cortical volume), NGMV (normalized gray matter volume), NWMV (normalized white matter volume), RIS (Radiologically isolated syndrome), RRMS (relapsing-remitting multiple sclerosis), SD (standard deviation), WM (white matter), WMLV (white matter lesion volume)
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      References

        • Amato MP
        • Hakiki B
        • Goretti B
        • et al.
        Association of MRI metrics and cognitive impairment in radiologically isolated syndromes.
        Neurology. 2012; 78: 309-314https://doi.org/10.1212/WNL.0b013e31824528c9
        • De Stefano N
        • Stromillo ML
        • Rossi F
        • et al.
        Improving the characterization of radiologically isolated syndrome suggestive of multiple sclerosis.
        PLoS One. 2011; 6: e19452https://doi.org/10.1371/journal.pone.0019452
        • Eijlers AJC
        • van Geest Q
        • Dekker I
        • et al.
        Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study.
        Brain. 2018; 141: 2605-2618https://doi.org/10.1093/brain/awy202
        • Labiano-Fontcuberta A
        • Martínez-Ginés ML
        • Aladro Y
        • et al.
        A comparison study of cognitive deficits in radiologically and clinically isolated syndromes.
        Mult. Scler. 2016; 22: 250-253https://doi.org/10.1177/1352458515591072
        • Labiano-Fontcuberta A
        • Mato-Abad V
        • Álvarez-Linera J
        • et al.
        Gray matter involvement in radiologically isolated syndrome.
        Medicine (Baltimore). 2016; 95: e3208https://doi.org/10.1097/MD.0000000000003208
        • Lebrun C
        • Blanc F
        • Brassat D
        • et al.
        Cognitive function in radiologically isolated syndrome.
        Mult. Scler. 2010; 16: 919-925https://doi.org/10.1177/1352458510375707
        • Okuda DT
        • Mowry EM
        • Beheshtian A
        • et al.
        Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome.
        Neurology. 2009; 72: 800-805https://doi.org/10.1212/01.wnl.0000335764.14513.1a
        • Okuda DT
        • Siva A
        • Kantarci O
        • et al.
        Radiologically isolated syndrome: 5-year risk for an initial clinical event.
        PLoS One. 2014; 9: e90509https://doi.org/10.1371/journal.pone.0090509
        • Pravatà E
        • Rocca MA
        • Valsasina P
        • et al.
        Gray matter trophism, cognitive impairment, and depression in patients with multiple sclerosis.
        Mult. Scler. 2017; 23: 1864-1874https://doi.org/10.1177/1352458517692886
        • Rojas JI
        • Patrucco L
        • Míguez J
        • Besada C
        • Cristiano E.
        Brain atrophy in radiologically isolated syndromes.
        J. Neuroimaging. 2015; 25: 68-71https://doi.org/10.1111/jon.12182