Highlights
- •Persons with late-onset multiple sclerosis (PwLOMS) have faster disability accrual than matched adult-onset MS (AOMS)
- •PwLOMS had significantly greater MSSS scores to AOMS
- •PwLOMS have greater ventricular expansion when compared to adult-onset MS
Abstract
Background
Late-onset multiple sclerosis (LOMS) is associated with faster disability progression
than persons with adult-onset MS (PwAOMS). The differences in brain atrophy are currently
unknown.
Objectives
To determine MRI-derived atrophy rates in persons with late-onset MS (PwLOMS) and
compare them to an age-matched and disease duration-matched sample of PwAOMS.
Methods
870 persons with MS (290 PwLOMS, 290 age-matched PwAOMS, and 290 disease duration-matched
PwAOMS), and 150 healthy controls (HCs), were followed for 5 years and 3 years, respectively.
Cross-sectional and longitudinal measures of T2-lesion volume (LV), lateral ventricular
volume (LVV) and whole brain volume (WBV) were derived. Expanded Disability Status
Scale (EDSS) and Multiple Sclerosis Severity Score (MSSS) were calculated. Both analyses
were corrected for false discovery rate.
Results
Persons with MS exhibited significantly greater annualized WBV loss (-0.88% vs. -0.38%,
p<0.001) and annualized LVV expansion (3.1% vs. 1.7%, p=0.002) when compared to HCs.
PwLOMS had significantly higher baseline and follow-up median MSSS when compared to
both age-matched and disease duration-matched PwAOMS (p<0.026). PwLOMS showed significantly
greater percent LVV change (14.3% vs. 9.3% p=0.001) and greater annualized percent
LVV change (4.1% vs. 1.6%, p<0.001) compared to age-matched PwAOMS.
Conclusion
PwLOMS had higher MSSS and greater ventricle expansion when compared to PwAOMS.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Multiple Sclerosis and Related DisordersAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Is Time to Reach EDSS 6.0 Faster in Patients with Late-Onset versus Young-Onset Multiple Sclerosis?.PLoS One. 2016; 11e0165846
- Multiple sclerosis in the elderly patient.Drugs Aging. 2010; 27: 283-294
- Subclinical motor impairment assessed with an engineered glove correlates with magnetic resonance imaging tissue damage in radiologically isolated syndrome.Eur J Neurol. 2019; 26: 162-167
- Age is a critical determinant in recovery from multiple sclerosis relapses.Mult Scler. 2018; 01352458518800815
- Late onset and young onset relapsing remitting multiple sclerosis. Evidence from a retrospective long-term follow-up study.Eur J Neurol. 2018;
- Prodromal symptoms of multiple sclerosis in primary care.Ann Neurol. 2018; 83: 1162-1173
- Atrophied Brain Lesion Volume: A New Imaging Biomarker in Multiple Sclerosis.J Neuroimaging. 2018; 28: 490-495
- Establishing pathological cut-offs for lateral ventricular volume expansion rates.Neuroimage Clin. 2018; 18: 494-501
- Neurological software tool for reliable atrophy measurement (NeuroSTREAM) of the lateral ventricles on clinical-quality T2-FLAIR MRI scans in multiple sclerosis.Neuroimage Clin. 2017; 15: 769-779
- The effect of hypointense white matter lesions on automated gray matter segmentation in multiple sclerosis.Hum Brain Mapp. 2012; 33: 2802-2814
- Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis.Radiology. 2019; 293: 424-433
- Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine.AJNR Am J Neuroradiol. 2018; 39: 2237-2242
- Aging and Brain Atrophy in Multiple Sclerosis.J Neuroimaging. 2019; 29: 527-535
- Older Age at Multiple Sclerosis Onset Is an Independent Factor of Poor Prognosis: A Population-Based Cohort Study.Neuroepidemiology. 2017; 48: 179-187
- Gray matter atrophy and disability progression in patients with early relapsing-remitting multiple sclerosis: a 5-year longitudinal study.J Neurol Sci. 2009; 282: 112-119
- Hypertension and heart disease are associated with development of brain atrophy in multiple sclerosis: a 5-year longitudinal study.Eur J Neurol. 2019; 26: 87-e88
- MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths.Neuroimage. 2009; 46: 177-192
- The 11-year long-term follow-up study from the randomized BENEFIT CIS trial.Neurology. 2016; 87: 978-987
- Clinical characteristics of patients with late-onset multiple sclerosis.J Neurol. 2008; 255: 697-702
- Incidence of MS has increased markedly over six decades in Denmark particularly with late onset and in women.Neurology. 2018;
- Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).Neurology. 1983; 33: 1444-1452
- Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria.Ann Neurol. 2011; 69: 292-302
- Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria".Ann Neurol. 2005; 58: 840-846
- Late onset multiple sclerosis: Is it really late onset?.Mult Scler Relat Disord. 2014; 3: 444-449
- Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity.Neurology. 2005; 64: 1144-1151
- Age and disability accumulation in multiple sclerosis.Neurology. 2011; 77: 1246-1252
- Accurate, robust, and automated longitudinal and cross-sectional brain change analysis.Neuroimage. 2002; 17: 479-489
- Brain reserve against physical disability progression over 5 years in multiple sclerosis.Neurology. 2016; 86: 2006-2009
- Multiple sclerosis.The Lancet. 2018; 391: 1622-1636
- Is late-onset multiple sclerosis associated with a worse outcome?.Neurology. 2006; 67: 954-959
- Age-related disability in multiple sclerosis.Ann Neurol. 2002; 51: 475-480
- Epidemiology and treatment of multiple sclerosis in elderly populations.Nat Rev Neurol. 2019; 15: 329-342
- Meta-analysis of the Age-Dependent Efficacy of Multiple Sclerosis Treatments.Front Neurol. 2017; 8: 577
- A significant decrease in diagnosis of primary progressive multiple sclerosis: A cohort study.Mult Scler. 2016;
- Thalamic atrophy is associated with development of clinically definite multiple sclerosis.Radiology. 2013; 268: 831-841
- Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis: a case-control study.Neuroimage. 2012; 59: 331-339
- A Serial 10-Year Follow-Up Study of Atrophied Brain Lesion Volume and Disability Progression in Patients with Relapsing-Remitting MS.AJNR Am J Neuroradiol. 2019; 40: 446-452
- Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine.Expert Rev Neurother. 2016; 16: 777-793
Article info
Publication history
Published online: October 16, 2020
Accepted:
October 16,
2020
Received in revised form:
October 15,
2020
Received:
May 30,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
