Despite a small population size of up to 17,000 patients in the United States and
an incidence of one in 100,000 persons worldwide (
Flanagan et al., 2016
;
- Flanagan E.P.
- Cabre P.
- Weinshenker B.G.
- Sauver J.S.
- Jacobson D.J.
- Majed M.
- Lennon V.A.
- Lucchinetti C.F.
- McKeon A.
- Matiello M.
- Kale N.
- Wingerchuk D.M.
- Mandrekar J.
- Sagen J.A.
- Fryer J.P.
- Robinson A.B.
- Pittock S.J.
Epidemiology of aquaporin-4 autoimmunity and neuromyelitis optica spectrum.
Ann. Neurol. 2016; 79: 775-783
Marrie and Gryba, 2013
;
Mealy et al., 2012
), neuromyelitis optica spectrum disorder (NMOSD) has attained disproportionate attention
over the past few years since the publication of three worldwide randomized placebo-controlled
therapeutic trials. In a recent editorial we discussed the first of three drugs to
gain approval from the US Food and Drug Administration (FDA) and the European Medicines
Agency – eculizumab, an inhibitor of complement C5 (
Pardo et al., 2019
). The second drug that was just approved in June 2020 is inebilizumab (
FDA, 2020
).To read this article in full you will need to make a payment
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Article info
Publication history
Published online: August 26, 2020
Identification
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© 2020 Elsevier B.V. All rights reserved.
