Creatine plays a pivotal role in brain bioenergetics, acting as a temporal and spatial
energy buffer, energy transducer, and metabolic regulator. A low cerebral creatine
concentration illustrating energy depletion has been routinely observed in various
neuropathologies, including cerebrovascular diseases, brain neoplasms, inborn disorders
of creatine metabolism, and age-related conditions. (
Niedzwiecki et al., 2020
) White matter disorders (WMD), however, appear to encounter a different dynamics
in brain creatine variation that could be potentially useful in the disease screening
and prognosis.To read this article in full you will need to make a payment
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Article info
Publication history
Published online: August 04, 2020
Accepted:
August 3,
2020
Received in revised form:
July 29,
2020
Received:
May 29,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
