Highlights
- •Valid assessment of treatment satisfaction is critical in the care of multiple sclerosis (MS).
- •Our results suggest the Functional Assessment of Chronic Illness Therapy – General Treatment Satisfaction (FACIT-TS-G) is a reliable and valid measure of patient-reported treatment satisfaction in MS.
- •These results also suggest infusible disease modifying treatments (DMTs) for MS are associated with greater treatment satisfaction compared to DMTs with oral or injection administration.
Abstract
Background
Patient-reported treatment satisfaction is associated with medication adherence and
persistence, making it increasingly important in the multiple sclerosis (MS) population,
where disease modifying treatments (DMTs) can be vital in preventing accumulation
of disability. Therefore, the valid assessment of treatment satisfaction is critical
in MS care. The current study aimed to examine the validity of the Functional Assessment
of Chronic Illness Therapy – General Treatment Satisfaction (FACIT-TS-G) in an MS
population.
Methods
Patient-reported outcome (PRO) data were collected from 555 MS patients (mean age
47.99±11.57; 76.4% female; 78.7% White/Caucasian) as part of routine clinical care.
The FACIT-TS-G reliability, validity, and factor structure were examined. FACIT-TS-G
scores were compared between DMT administration type (oral, injection, infusion) and
examined as a possible predictor of switching DMT type at 1-to-2-year follow-up.
Results
The FACIT-TS-G showed good internal consistency (Cronbach's α=0.836), convergent validity,
and known-group validity. Confirmatory factor analyses supported a single factor.
DMT infusion administration was associated with slightly greater FACIT-TS-G scores
than injection (p = 0.013, 95% CI: 0.269, 2.273) and oral administration (p = 0.030, 95% CI: 0.087, 1.717). FACIT-TS-G scores did not predict the likelihood
of switching DMT type at follow-up (p>0.05).
Conclusion
Our findings support the use of the FACIT-TS-G as a PRO measure of treatment satisfaction
in MS. Moreover, results suggest DMT administration via infusion is associated with
greater treatment satisfaction. Future research is needed to examine treatment satisfaction
in the context of other outcomes.
Keywords
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Article info
Publication history
Published online: July 18, 2020
Accepted:
July 17,
2020
Received in revised form:
July 16,
2020
Received:
May 22,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
