Highlights
- •This manuscript reports the evaluation of the neutrophil-to-lymphocyte ratio (NLR) both acutely and during remission in a cohort of 62 children with demyelinating syndrome.
- •The NLR has been previously shown to correlate with disease activity in systemic autoimmunity; with recent evaluation in central nervous system (CNS) disorders, such as MS and AQP4-Ab NMOSD.
- •In this cohort we observed that the NLR was higher only at time of clinical attack but not at time of remission in MOGAD, higher both at time of acute attack and remission in NMOSD and not different to that of controls neither during relapse nor remission in MS. The temporal correlation of NLR with MOGAD activity could be used as a supportive biomarker for acute relapse, given that the clinical differentiation between relapses and pseudo-relapses can be challenging.
Abstract
The neutrophil-to-lymphocyte ratio (NLR) was shown correlate with disease activity
in systemic autoimmunity and MS. In a cohort of 62 children with demyelinating diseases;
NLR was high both acutely (P<.001) and during remission (P=.01) in AQP4-Ab NMOSD; higher only at time of clinical attack (P<.001) but not at time of remission in MOGAD and not different to that of controls
neither during relapse nor remission in MS. The temporal correlation of NLR with MOGAD
activity could be used as a supportive biomarker for acute relapse, given that the
clinical differentiation between relapses and pseudo-relapses can be challenging.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Multiple Sclerosis and Related DisordersAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The clinical significance of the neutrophil-to-lymphocyte ratio in multiple sclerosis.Int. J. Neurosci. 2016; 126: 700-706
- Neutrophil to lymphocyte ratio may be a helpful marker to evaluate disease activity in NMOSD.Neurol. Sci. 2017; 38: 1859-1863
- The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis.BMC Neurol. 2019; 19: 23
- The neutrophil-to-lymphocyte ratio as disease actvity marker in multiple sclerosis and optic neuritis.Mult. Scler. Relat. Disord. 2017; 18: 213-217
- Diagnostic algorithm for relapsing acquired demyelinating syndromes in children.Neurology. 2017; 89: 269-278
- Treatment approaches for MOG-Ab-associated demyelination in children.Curr. Treat. Options Neurol. 2019; 21: 2
- Relevance of antibodies to myelin oligodendrocyte glycoprotein in CSF of seronegative cases.Neurology. 2019; 93: e1867-e1e72
- Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein.Ann. Neurol. 2018;
Article info
Publication history
Published online: June 30, 2020
Accepted:
June 29,
2020
Received in revised form:
June 27,
2020
Received:
June 8,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
