Highlights
- •A specific social cognition impairment is described in Multiple Sclerosis patients.
- •Resting-state functional connectivity has found to be altered in Multiple Sclerosis.
- •Connectivity of fusiform cortex is related with social cognition impairment.
- •Visual processing areas are functionally related to social cognition.
- •Functional connectivity of amygdala is related with social cognition.
Abstract
Background: Multiple Sclerosis produces changes in the functional connectivity of
the brain. Resting-State fMRI is a useful tool for the study of functional changes
in the human brain, and its metrics can be related to clinical findings involved in
clinical decline. Social cognition has focused increasing interest because patients
are exposed to experiencing social disorganization during the progression of the disease.
fMRI has proved to be a useful tool for studying brain connectivity and its relation
with social cognition both in resting-state and during socio-cognitive tasks.
Objective. to identify functional changes during rest in Relapsing-Remitting Multiple
Sclerosis patients and look for a correlation with social cognition.
Methods. 45 patients with Relapsing-Remitting Multiple Sclerosis and 47 control subjects
were recruited to perform a neuropsychological evaluation of the social cognition
performance and to acquire resting-state fMRI.
Results. Patients exhibited lower performance in social cognition tasks, mostly related
to face emotion recognition. Decreased functional connectivity in patients is seen
concerning the right anterior insula, middle frontal, and occipital regions while
increased connectivity is mostly related to the occipital and visual areas. The connectivity
of the fusiform cortex and the amygdala is related to the performance in emotion recognition
and Theory of Mind tasks respectively.
Conclusion. Social cognition compromise was found in this sample. Functional connectivity
changes during rest were detected and correlated with social cognition changes in
patients.
Keywords
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Article info
Publication history
Published online: June 23, 2020
Accepted:
June 22,
2020
Received in revised form:
June 21,
2020
Received:
April 9,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
