There are several types of autoimmune encephalitis which share overlapping neuroimaging
findings and clinical features, often identified and differentiated by the specific
antibody type. Anti-glutamic acid decarboxylase (GAD) antibodies bind to GAD enzyme,
and are essential in formation of γ-aminobutyric acid (GABA), the primary inhibitory
neurotransmitter of the brain. Patients testing positive for this antibody present
with many different clinical pictures including limbic encephalitis, epilepsy, cerebellar
ataxia, and stiff-person syndrome, collectively known as “anti-GAD neurological syndromes”.
We present a rare case of GAD-65 antibody associated encephalitis, with large hemispheric
lesions on imaging.
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References
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Article info
Publication history
Published online: June 22, 2020
Accepted:
June 21,
2020
Received in revised form:
June 10,
2020
Received:
April 28,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
