Highlights
- •Vestibulo-ocular reflex pathway may be affected in the early stages of the MS.
- •The central involvement in MS has an impact on vestibulo-ocular system.
- •The patients with MS and central vestibular pathology frequently describe their complaint as “dizziness”.
Abstract
Background
Multiple Sclerosis (MS), an autoimmune demyelinating disease of the central nervous
system, is an important cause of disability in young adults. The purpose of this cross-sectional
study was to evaluate the vestibular system with video Head Impulse Test (vHIT) and
determine the impairment of the Vestibulo-ocular Reflex (VOR) in childhood-onset MS.
Methods
The study group, 20 persons with MS (pwMS) with onset before 18 years of age (6 M,
14 F; mean age 19.06 ± 1.66) and the control group, 20 healthy, age- and sex-matched
individuals were retrieved from vHIT recordings. The mean age of MS onset in the study
group was 14.60 ± 1.53 years. The VOR pathway was evaluated using vHIT.
Results
The median VOR gains of right anterior (1.00), left lateral (0.96) and left posterior
(0.91) semicircular canals were significantly lower in the pwMS group than those of
the healthy control group (1.05, 1.00, 0.98 respectively, p < 0.05). Four of pwMS (20%) had abnormal VOR gains. The pwMS with dizziness had significantly
lower VOR gains (median 0.91) compared with pwMS without dizziness (median 1.01, p < 0.05).
Conclusion
This study demonstrates vestibulo-ocular system can be affected in patients with childhood-onset
MS and suggests using vHIT especially in the follow-up of pwMS with dizziness.
Keywords
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Article info
Publication history
Published online: June 22, 2020
Accepted:
June 21,
2020
Received in revised form:
June 16,
2020
Received:
May 11,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
