Abstract
Background Cognitive impairment is common in multiple sclerosis (MS) patients with
43-70% of patients being affected. The international cognitive assessment for MS BICAMS
is a new battery for cognitive assessment in MS patients. It was suggested in 2012
that international validation efforts be undertaken.
Objective To utilize regression to provide normative values for the BICAMS while correcting
for age, gender and education, as well as assess test-retest reliability, in an Arab
population.
Methods Healthy subjects were recruited from different areas in Dubai. Corrections
for demographics were calculated using multiple linear regression. Test-retest reliability
was assessed using the Pearson correlation coefficient.
Results Two hundred eighty-one healthy subjects were enrolled (174 women, mean age
30±10.3 years, mean education 17.8±3.7 years). Test re-test results showed significant
correlation between baseline and retest scores. Regression-based equations were derived
for the BICAMS.
Conclusion This large-scale validation study provides evidence to support the facilitation
of international implementation of the BICAMS assessment by focusing on the Arab population.
Next steps include validation efforts in an Arab MS patient population to further
support the use of the BICAMS in day to day practice and for longitudinal patient
assessment.
Keywords
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Article info
Publication history
Published online: June 14, 2020
Accepted:
June 12,
2020
Received in revised form:
June 1,
2020
Received:
December 23,
2019
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
