Highlights
- •The results of previous studies on whether coffee consumption can decrease the risk of multiple sclerosis are conflicting.
- •We found no evidence for the casual effect of coffee consumption on the risk of multiple sclerosis using Mendelian randomization analysis.
- •Further well-designed genetic-epidemiological studies investigating the effect of coffee intake on the disease course, such as relapse and progression, are warranted.
Abstract
Objective
. Coffee consumption has been suggested to decrease the risk of multiple sclerosis
(MS). In this study, we aim to investigate the causal effect of coffee consumption
on risk of MS by Mendelian randomization (MR) approaches.
Methods
. Through a genome-wide association study including 375,833 participants from UK Biobank,
we obtained single-nucleotide polymorphisms (SNPs) associated with habitual coffee
consumption (P < 5 × 10−8). Summary-level data for MS were obtained from a meta-analysis, incorporating 14,802
subjects with MS and 26,703 healthy controls of European ancestry, which was conducted
by the International Multiple Sclerosis Genetics Consortium. MR analyses were performed
using inverse-variance-weighted method, weighted median estimator, and MR-Egger regression.
Additional analyses were further performed using MR-Egger intercept and Cochran's
Q statistic to verify the robustness of our findings.
Results
. Nine coffee-associated SNPs were selected as instrumental variables. We failed to
detect a causal effect of coffee consumption on MS risk (odds ratio, 1,00; 95% confidence
interval, 0.98-1.01; P = 0.48). In the main MR analysis. Consistent results were yielded in sensitivity
analyses using the weighted median and MR-Egger methods, and no horizontal pleiotropy
(P = 0.49) was identified.
Conclusion
. Our MR results indicated that coffee consumption might not be causally associated
with risk of MS occurrence. Further well-designed genetic-epidemiological studies
investigating the effect of coffee intake on the disease course, such as relapse and
progression, are warranted.
Keywords
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Article info
Publication history
Published online: June 11, 2020
Accepted:
June 10,
2020
Received in revised form:
June 8,
2020
Received:
May 19,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
