Abstract
Background
Emerging evidence indicated that gut microbiota might play an essential role in the
pathogenesis of neuromyelitis optica spectrum disorders (NMOSD). The results are highly
heterogeneous and mainly conducted in the patients of NMOSD AQP4+ status.
Methods
16S ribosomal RNA gene sequencing targeting V3-V4 region was performed on fecal samples
of 50 individuals, subdivided into NMOSD AQP4+ group (P1, n=14) and NMOSD AQP4− group
(P2, n=8), and healthy controls (C, n=28).
Results
Fecal microbiome analyses revealed that gut microbial diversity and composition were
distinctly different between NMOSD patients and controls. We also found that amounts
of specific genera were correlated with disease-specific parameters. Remarkably, 9
genus-level microbial biomarkers were identified and acquired an area under the curve
(AUC) of 0.97 between NMOSD patients and controls.
Conclusions
This study is the first to characterize gut microbiota features in NMOSD patients
of AQP4+ status and AQP4− status. Further analysis revealed that both AQP4+ and AQP4− groups had certain unique microbiota profiles and metabolic pathways. Taking together,
these findings not only support for NMOSD to the growing list of diseases associated
with gut microbial alterations, but also suggest that the gut microbiota biomarkers
may be a target for individualized treatment in future.
Keywords
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Article info
Publication history
Published online: May 25, 2020
Accepted:
May 18,
2020
Received in revised form:
May 16,
2020
Received:
August 18,
2019
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
