Emerging evidence indicated that gut microbiota might play an essential role in the pathogenesis of neuromyelitis optica spectrum disorders (NMOSD). The results are highly heterogeneous and mainly conducted in the patients of NMOSD AQP4+ status.
16S ribosomal RNA gene sequencing targeting V3-V4 region was performed on fecal samples of 50 individuals, subdivided into NMOSD AQP4+ group (P1, n=14) and NMOSD AQP4− group (P2, n=8), and healthy controls (C, n=28).
Fecal microbiome analyses revealed that gut microbial diversity and composition were distinctly different between NMOSD patients and controls. We also found that amounts of specific genera were correlated with disease-specific parameters. Remarkably, 9 genus-level microbial biomarkers were identified and acquired an area under the curve (AUC) of 0.97 between NMOSD patients and controls.
This study is the first to characterize gut microbiota features in NMOSD patients of AQP4+ status and AQP4− status. Further analysis revealed that both AQP4+ and AQP4− groups had certain unique microbiota profiles and metabolic pathways. Taking together, these findings not only support for NMOSD to the growing list of diseases associated with gut microbial alterations, but also suggest that the gut microbiota biomarkers may be a target for individualized treatment in future.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Multiple Sclerosis and Related Disorders
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Alterations in intestinal microbiota correlate with susceptibility to type 1 diabetes.Diabetes. 2015; 64: 3510-3520https://doi.org/10.2337/db14-1847
- Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system.Eur. J. Neurol. 2013; 20: 1492-1495https://doi.org/10.1111/ene.12072
- Metabolic endotoxemia initiates obesity and insulin resistance.Diabetes. 2007; 56: 1761-1772https://doi.org/10.2337/db06-1491
- Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls.Sci. Rep. 2016; 6: 28484https://doi.org/10.1038/srep28484
- The interplay between the intestinal microbiota and the brain.Nat. Rev. Microbiol. 2012; 10: 735-742https://doi.org/10.1038/nrmicro2876
- Gut microbiome analysis in neuromyelitis optica reveals overabundance of clostridium perfringens.Ann. Neurol. 2016; 80: 443-447https://doi.org/10.1002/ana.24718
- Age-and sex-dependent patterns ofgut microbial diversity in human adults.mSystems. 2019; 4 (pii:e00261-19)https://doi.org/10.1128/mSystems.00261-19
- Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.Nature. 2013; 504: 446-450https://doi.org/10.1038/nature12721
- Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis optica spectrum disorders: a Chinese pilot study.Mult. Scler. 2019; 25https://doi.org/10.1177/1352458518790396
- The gut microbiota and inflammatory bowel disease.Curr. Opin. Rheumatol. 2015; 27: 388-396https://doi.org/10.1097/BOR.0000000000000192
- Intestinal dysbiosis associated with systemic lupus erythematosus.MBio. 2014; 5 (e01548-14)https://doi.org/10.1128/mBio.01548-14
- Intestinal dysbiosis and rheumatoid arthritis: a link between gut microbiota and the pathogenesis of rheumatoid arthritis.J.Immunol. Res. 2017; 20174835189https://doi.org/10.1155/2017/4835189
- Alterations of the human gut microbiome in multiple sclerosis.Nat. Commun. 2016; 7: 12015https://doi.org/10.1038/ncomms12015
- A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis.Lancet. 2004; 364: 2106-2112https://doi.org/10.1016/S0140-6736(04)17551-X
- Alteration of the fecal microbiota in Chinese patients with Parkinson's disease.Brain Behav. Immun. 2018; 70: 194-202https://doi.org/10.1016/j.bbi.2018.02.016
- The first 1000 cultured species of the human gastrointestinal microbiota.FEMS Microbiol. Rev. 2014; 38: 996-1047https://doi.org/10.1111/1574-6976.12075
- The gut microbiome in human neurological disease: a review.Ann. Neurol. 2017; 81 (101002/ana.24901): 369-382
- Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize clostridium ABC transporter.Ann. Neurol. 2012; 72: 53-64https://doi.org/10.1002/ana.23651
- International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.Neurology. 2015; 85: 177-189https://doi.org/10.1212/WNL.0000000000001729
- Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis.Neurochem. Int. 2019; 129104486https://doi.org/10.1016/j.neuint.2019.104468
Published online: May 25, 2020
Accepted: May 18, 2020
Received in revised form: May 16, 2020
Received: August 18, 2019
© 2020 Elsevier B.V. All rights reserved.