Highlights
- •Multiple sclerosis is a chronic demyelinating and inflammatory disease that lacks tools for diagnosis and prognosis.
- •Lipids and oxidized lipids are importante players on inflammation and disease progression.
- •Lipidomics is a promising tool to identify new lipid biomarkers of multiple sclerosis.
Abstract
Multiple sclerosis is a chronic inflammatory and neurodegenerative disease of the
central nervous system, and it is one of the most common neurological cause of disability
in young adults. It is known that several factors contribute to increase the risk
of development and pathogenesis of multiple sclerosis, nonetheless, but the true etiology
of this pathology remains unknown. Similar to other inflammatory diseases, oxidative
stress and lipid peroxidation are also associated to multiple sclerosis. Alterations
in the lipid profile seem to be a hallmark of this pathology which can contribute
to the dysregulation of lipid homeostasis and lipid metabolism in multiple sclerosis.
Lipidomic studies analysed in this review clearly demonstrate the role of lipids in
inflammatory processes, in immunity, and in the onset and development of multiple
sclerosis. Several investigations reported alterations of some molecular lipid species,
in particular, with decrease of fatty acids (FA) 18:2 and 20:4 and total polyunsaturated
FA, with compensatory increases of saturated FA with shorter carbon chains. Oxidized
phospholipids were reported in few studies as well. Also, it was shown that clinical
lipidomics has potential as a tool to aid both in multiple sclerosis diagnosis and
therapeutics by allowing a detailed lipidome profiling of the patients suffering with
this disease.
Keywords
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Article info
Publication history
Published online: May 29, 2020
Accepted:
May 6,
2020
Received in revised form:
May 5,
2020
Received:
January 22,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
