Highlights
- •NMOSD patients may encounter cognitive impairment.
- •It seems that vitamin B6 intake is associated with cognitive function.
- •Dietary B6 showed positive correlation with cognitive function in NMOSD patients.
Abstract
Introduction
Given some evidence on the effects of vitamin B6 on cognitive function and the high
prevalence of cognitive impairment in patients with Neuromyelitis Optica Spectrum
Disorder (NMOSD), we conducted the present study to evaluate the correlation between
dietary vitamin B6 intake and cognitive function among NMOSD patients.
Method
A cross-sectional study was designed on 24 definite NMOSD patients in Sina hospital,
Tehran, Iran. A validated 168-item food frequency questionnaire was used to obtain
the participants’ routine dietary habits. For the cognitive function assessment, Minimal
Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery was administered.
Vitamin B6 intake per day was calculated, and the correlation between vitamin B6 and
the results of MACFIMS subtests was examined.
Results
The results revealed a positive correlation between dietary vitamin B6 intake and
cognitive function in all subtests of MACFIMS. This direct correlation was significant
in case of verbal and learning memory according to CVLT-II subtest (p-value:0.02; r:0.45) as well as speed of information processing and working memory
according to SDMT subtest (p-value:0.04; r:0.43). The results from linear regression analysis adjusted for carbohydrate
intake and disease duration indicated a significant ascending trend for the score
of CVLT-II, SDMT, CVLT-II-delayed recall, and Brief Visuospatial Memory Test-Revised
(BVMT-R) subtests through the quartiles of vitamin B6 intakes.
Conclusion
Our finding indicated a positive correlation between higher dietary intake of vitamin
B6 and cognitive function of NMOSD patients. Based on high prevalence of cognitive
malfunction in NMOSD patients, these results are promising.
Keywords
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Article info
Publication history
Published online: April 28, 2020
Accepted:
April 13,
2020
Received in revised form:
April 7,
2020
Received:
March 17,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
