Highlights
- •MOG-IgG in serum denotes an emerging autoimmune CNS disorder.
- •We report a case of MOG-IgG demyelination with MS-phenotype.
- •Immunotherapies approved for MS may not be effective in this condition.
- •In our patient effective disease control could be achieved with alemtuzumab.
Abstract
Immunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein in serum
denote an emerging autoimmune disorder of the central nervous system. Treatment trials
have not been performed so far and anecdotal reports suggest that immunotherapies
approved for multiple sclerosis (MS) may not be effective. We report favorable disease
control with alemtuzumab, a CD52 depleting antibody approved for active MS, in a 34-year-old
woman with the rarer condition of MOG-IgG disease with MS-phenotype. MOG-IgG in serum
persisted over the entire observation period of almost five years. This case emphasizes
that treatment responses may be distinct for different phenotypes of MOG-IgG associated
disease.
Keywords
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Article info
Publication history
Published online: April 15, 2020
Accepted:
April 6,
2020
Received in revised form:
April 5,
2020
Received:
March 20,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
