- •Drug reaction with eosinophilia and systemic symptoms (DRESS) occurs rarely with biological drugs.
- •DRESS-related symptoms include fever, cutaneous eruption, internal organ involvement, and hematologic abnormalities.
- •If DRESS-like symptoms occur, prompt withdrawal of the suspected medication is indicated.
- •Antihistamine treatment is recommended and administration of oral corticosteroids may be necessary.
We report here on a young woman with multiple sclerosis, who developed a condition with eosinophilia and swelling of limbs seven weeks after initiation of ocrelizumab treatment. We consider her drug reaction to be compatible with a drug reaction with eosinophilia and systemic symptoms (DRESS), also called drug-induced hypersensitivity syndrome. She was treated with antihistamine and corticosteroid treatments, and recovered fully within three months of symptom onset. Ocrelizumab was not re-initiated. We are not aware of other DRESS-like cases related to ocrelizumab treatment.
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Published online: March 14, 2020
Accepted: March 13, 2020
Received in revised form: March 11, 2020
Received: January 17, 2020
© 2020 Elsevier B.V. All rights reserved.