Highlights
- •Drug reaction with eosinophilia and systemic symptoms (DRESS) occurs rarely with biological drugs.
- •DRESS-related symptoms include fever, cutaneous eruption, internal organ involvement, and hematologic abnormalities.
- •If DRESS-like symptoms occur, prompt withdrawal of the suspected medication is indicated.
- •Antihistamine treatment is recommended and administration of oral corticosteroids may be necessary.
Abstract
We report here on a young woman with multiple sclerosis, who developed a condition
with eosinophilia and swelling of limbs seven weeks after initiation of ocrelizumab
treatment. We consider her drug reaction to be compatible with a drug reaction with
eosinophilia and systemic symptoms (DRESS), also called drug-induced hypersensitivity
syndrome. She was treated with antihistamine and corticosteroid treatments, and recovered
fully within three months of symptom onset. Ocrelizumab was not re-initiated. We are
not aware of other DRESS-like cases related to ocrelizumab treatment.
Keywords
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References
European Medicines Agency (2018) - European public assessment report (EPAR) - Ocrevus. Ema.
- Eosinophilic drug allergy.Clin. Rev. Allergy Immunol. 2016; 50: 228-239
- Nivolumab-associated DRESS syndrome: a case report.JAAD Case Rep. 2019; 5: 216-218
- Drug reaction with eosinophilia and systemic symptoms after daclizumab therapy.Neurology. 2018; 91: E359-E363
- DRESS syndrome caused by efalizumab.Clin. Exp. Dermatol. 2008; 33: 50-52
Article info
Publication history
Published online: March 14, 2020
Accepted:
March 13,
2020
Received in revised form:
March 11,
2020
Received:
January 17,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
