Highlights
- •MOG-Ab-associated disease is a distinct entity with various clinical phenotypes.
- •Epileptic seizures may be one of the core symptoms in this disease.
- •A meta-analysis about the occurrence of epileptic seizures in this disease.
- •Acute epileptic seizures are common in MOG-Ab-associated disease.
Abstract
Objective
Recent reports have suggested that seizures may be a component of the clinical presentation
in myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease. We aimed
to conduct a systematic review and meta-analysis to comprehensively evaluate the occurrence
of epileptic seizures in the disease.
Methods
We searched PubMed, MEDLINE and EMBASE for studies reporting the occurrence of acute
symptomatic seizures in MOG-Ab-associated disease. Fixed or random effects model was
used to pool results across studies with a meta-analysis.
Results
A total of 14 studies met the inclusion criteria. Overall, acute symptomatic seizures
were observed in 20.5% (95% confidence interval [CI] 13.7%-30.7%, I2=60.6%) patients with MOG-Ab-associated disease, and in a similar proportion of children
respectively (20.0%; 95% CI 14.3%-27.8%, I2=7.0%). The pooled probability of seizure occurrence in males was 30.1% (95% CI 17.5%-52%,
I2=0.0%) while that in females was much lower (12.0%; 95% CI 5.5%-26.4%, I2=0.0%). Furthermore, when we focused on those with acute disseminated encephalomyelitis-like
phenotype, 37.3% patients experienced seizures (95% CI 21.0%-66.3%, I2=55.8%).
Conclusions
Our study suggested that epileptic seizures were common in MOG-Ab-associated disease
and offered insight into associated factors that contribute to the occurrence of seizures.
Future studies with explicit evaluation are required.
Keywords
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Article info
Publication history
Published online: March 14, 2020
Accepted:
March 13,
2020
Received in revised form:
February 25,
2020
Received:
November 30,
2019
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
