Highlights
- •T2 sagittal MRI brain has high specificity (>97%) for optic neuropathy (ON).
- •T2 sagittal MRI with 3 mm slice thickness has higher sensitivity for ON than 4 mm.
- •The sensitivity for ON is 85% when using 3 mm slice thickness.
- •Sensitivity is poor in the intraorbital nerve segment, 69% at 3 mm slice thickness.
Abstract
Background
Detection of optic neuropathy on MRI has potential implications for the diagnosis
and management of Multiple Sclerosis (MS).
Objective
This study assessed the accuracy of T2 sagittal MRI brain for detection of optic neuropathy,
compared to coronal STIR orbit.
Methods and materials
Retrospective single-center blinded diagnostic accuracy study of 100 consecutive patients
who underwent both T2 sagittal brain and coronal STIR orbit MRI. All were performed
on 1.5T scanners. T2 sagittal slice thickness was 4 mm for the first 50 patients (group1)
and 3 mm for the second 50 (group2). The MRIs were reviewed in a blinded fashion to
determine the presence of optic neuropathy. Coronal STIR orbit sequences were considered
the diagnostic reference standard.
Results
The sensitivity of T2 sagittal brain imaging for ON was 44% in group 1 and 85% in
group 2 (p = 0.007). The specificities were 98% and 97% respectively (p = 0.9). Sensitivity was poorest for evaluation of the intraorbital nerve segment
(56% grp1, 69% grp2, p = 0.4).
Conclusion
T2 sagittal MRI brain has high specificity for the detection of optic neuropathy when
compared to coronal STIR orbit. Sensitivity is increased when slice thickness is reduced,
but remains poor for evaluation of the intraorbital segment.
Keywords
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Article info
Publication history
Published online: November 12, 2019
Accepted:
November 11,
2019
Received in revised form:
November 9,
2019
Received:
August 26,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
