Abstract| Volume 37, 101527, January 2020

Demographic, Clinical and Paraclinical Characteristics of Multiple Sclerosis Mimickers Among a Sample of Egyptian Patients

      Multiple sclerosis (MS) is a chronic autoimmune disease which is the main cause of non-traumatic disability among young and middle-aged adults. The diagnosis of MS is not often feasible, whereas many disorders are mimicking MS.
      This study was implemented to identify the difference in demographics, clinical, and paraclinical characteristics of MS mimickers in order to ensure early diagnosis and adequate treatment of MS patients.
      All patients with clinically suspected MS and aged 18-60 years old were included. Those patients were divided based on Mcdonald's Criteria 2017 and the paraclinical assessment into two groups: patients with confirmed MS diagnosis and those diagnosed with MS mimickers.
      In the current study, 515 patients with suspected diagnosis of MS were enrolled. Out of the, 400 (77.6 %) patients were diagnosed with MS and 115 (22.4%) patients did not fulfill the revised Mcdonald's criteria and thus were considered MS mimickers. The mimickers diagnoses included thirty cases (26.15%) migraine, twelve cases (10.4%) radiological isolated syndrome, eleven cases (9.6%) small vessel disease, ten cases (8.7%) psychogenic, eight cases (7%) neuromyelitis optica, five cases (4.3%) systemic lupus erythematosus, five cases (4.3%) Behcet's disease, five cases (4.3%) anterior ischemic optic neuropathy, four cases (3.5%) antiphospholipid syndrome, and four cases (3.5%) transverse myelitis.
      Patients with suspected diagnosis of MS should be subjected to meticulous neurological assessment coupled with magnetic resonance imaging (MRI) and appropriate laboratory investigations to confirm a definite diagnosis.