Advertisement
Case report| Volume 38, 101500, February 2020

Anti-myelin oligodendrocyte glycoprotein antibody-positive acute disseminated encephalomyelitis mimicking limbic encephalitis: A case report

Published:November 05, 2019DOI:https://doi.org/10.1016/j.msard.2019.101500

      Highlights

      • A case with MOG-ab-positive ADEM involving bilateral medial temporal lesions.
      • Part of the clinical manifestations resembled characteristics of limbic encephalitis.
      • The case seemed to have more than a limbic encephalitis, resulting in the diagnosis.
      • The need to evaluate MOG-ab in encephalomyelitis involving bilateral limbic system.

      Abstract

      Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-ab) have been detected in various disorders of the central nervous system including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorders (NMOSD), optic neuritis, myelitis, and cortical encephalitis. We report an atypical case of MOG-ab-associated encephalomyelitis with part of the clinical manifestations resembling limbic encephalitis. Multifocal, hyperintense, bilateral lesions predominantly affecting the white matter on brain magnetic resonance imaging and marked response to steroid therapy were compatible with a MOG-ab-associated disease. This case illustrates that MOG-ab-associated disease should be considered in encephalomyelitis involving the bilateral limbic system.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Multiple Sclerosis and Related Disorders
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Baumann M.
        • Sahin K.
        • Lechner C.
        • Hennes E.M.
        • Schanda K.
        • Mader S.
        • Karenfort M.
        • Selch C.
        • Häusler M.
        • Eisenkölbl A.
        • Salandin M.
        • Gruber-Sedlmayr U.
        • Blaschek A.
        • Kraus V.
        • Leiz S.
        • Finsterwalder J.
        • Gotwald T.
        • Kuchukhidze G.
        • Berger T.
        • Reindl M.
        • Rostásy K.
        Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein.
        J. Neurol. Neurosurg. Psychiatry. 2015; 86: 265-272
        • Cobo-Calvo A.
        • Ruiz A.
        • Maillart E.
        • Audoin B.
        • Zephir H.
        • Bourre B.
        • Ciron J.
        • Collongues N.
        • Brassat D.
        • Cotton F.
        • Papeix C.
        • Durand-Dubief F.
        • Laplaud D.
        • Deschamps R.
        • Cohen M.
        • Biotti D.
        • Ayrignac X.
        • Tilikete C.
        • Thouvenot E.
        • Brochet B.
        • Dulau C.
        • Moreau T.
        • Tourbah A.
        • Lebranchu P.
        • Michel L.
        • Lebrun-Frenay C.
        • Montcuquet A.
        • Mathey G.
        • Debouverie M.
        • Pelletier J.
        • Labauge P.
        • Derache N.
        • Coustans M.
        • Rollot F.
        • De Seze J.
        • Vukusic S.
        • Marignier R.O.F.S.E.P.
        • NOMADMUS Study Group
        Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults: the Mogador study.
        Neurology. 2018; 90: e1858-e1869
        • Dubey D.
        • Pittock S.J.
        • Krecke K.N.
        • Morris P.P.
        • Sechi E.
        • Zalewski N.L.
        • Weinshenker B.G.
        • Shosha E.
        • Lucchinetti C.F.
        • Fryer J.P.
        • Lopez-Chiriboga A.S.
        • Chen J.C.
        • Jitprapaikulsan J.
        • McKeon A.
        • Gadoth A.
        • Keegan B.M.
        • Tillema J.M.
        • Naddaf E.
        • Patterson M.C.
        • Messacar K.
        • Tyler K.L.
        • Flanagan E.P.
        Clinical, radiologic, and prognostic features of myelitis associated with myelin oligodendrocyte glycoprotein autoantibody.
        JAMA Neurol. 2018; 76: 301-309
        • Jarius S.
        • Paul F.
        • Aktas O.
        • Asgari N.
        • Dale R.C.
        • de Seze J.
        • Franciotta D.
        • Fujihara K.
        • Jacob A.
        • Kim H.J.
        • Kleiter I.
        • Kümpfel T.
        • Levy M.
        • Palace J.
        • Ruprecht K.
        • Saiz A.
        • Trebst C.
        • Weinshenker B.G.
        • Wildemann B.
        MOG encephalomyelitis: international recommendations on diagnosis and antibody testing.
        J. Neuroinflamm. 2018; 15: 134
        • Mariotto S.
        • Monaco S.
        • Peschl P.
        • Coledan I.
        • Mazzi R.
        • Höftberger R.
        • Reindl M.
        • Ferrari S.
        MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome.
        BMC Neurol. 2017; 17: 190
        • Ogawa R.
        • Nakashima I.
        • Takahashi T.
        • Kaneko K.
        • Akaishi T.
        • Takai Y.
        • Sato D.K.
        • Nishiyama S.
        • Misu. T.
        • Kuroda H.
        • Aoki M.
        • Fujihara K.
        MOG antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy.
        Neurol. Neuroimmunol. Neuroinflamm. 2017; 4: e322
        • Wang L.
        • ZhangBao J.
        • Zhou L.
        • Zhang Y.
        • Li H.
        • Li Y.
        • Huang Y.
        • Wang M.
        • Lu C.
        • Lu J.
        • Zhao C.
        • Quan C.
        Encephalitis is an important clinical component of myelin oligodendrocyte glycoprotein antibodyassociated demyelination: a single-center cohort study in Shanghai.
        China Eur. J. Neurol. 2019; 26: 168-174
        • Sakai K.
        • Yoshita M.
        • Samuraki M.
        • Yamada M.
        Acute disseminated encephalomyelitis with medial temporal lesions mimicking acute limbic encephalitis.
        Clin. Neurol. Neurosurg. 2011; 113: 72-74