- •A case with MOG-ab-positive ADEM involving bilateral medial temporal lesions.
- •Part of the clinical manifestations resembled characteristics of limbic encephalitis.
- •The case seemed to have more than a limbic encephalitis, resulting in the diagnosis.
- •The need to evaluate MOG-ab in encephalomyelitis involving bilateral limbic system.
Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-ab) have been detected in various disorders of the central nervous system including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorders (NMOSD), optic neuritis, myelitis, and cortical encephalitis. We report an atypical case of MOG-ab-associated encephalomyelitis with part of the clinical manifestations resembling limbic encephalitis. Multifocal, hyperintense, bilateral lesions predominantly affecting the white matter on brain magnetic resonance imaging and marked response to steroid therapy were compatible with a MOG-ab-associated disease. This case illustrates that MOG-ab-associated disease should be considered in encephalomyelitis involving the bilateral limbic system.
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Published online: November 05, 2019
Accepted: November 4, 2019
Received in revised form: August 13, 2019
Received: June 19, 2019
© 2019 Elsevier B.V. All rights reserved.