- •MOG-IgG was seronegative during both inflammatory events.
- •Seroconversion was transient and during interferon-beta treatment.
- •No disease progression was observed under interferon-beta therapy.
Immunoglobulin G (IgG) autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG) have recently been associated with autoimmune CNS demyelination. We present the case of a 35-year-old patient who was seronegative for MOG-IgG (as confirmed by means of three independent immunoassays) during two corticosteroid-responsive attacks of brainstem encephalitis and optic neuritis, respectively, but turned positive for MOG-IgG under treatment with interferon-beta (IFN-beta), which was commenced 6 months after onset of the first attack. MOG-IgG serum levels declined after therapy was switched to glatiramer acetate. The fact that seroconversion was first observed under treatment with IFN-beta is in accordance with previous evidence suggesting a role of IFN-beta in disease exacerbation in antibody-mediated disorders.
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Published online: September 28, 2019
Accepted: September 27, 2019
Received in revised form: September 3, 2019
Received: July 26, 2019
© 2019 Elsevier B.V. All rights reserved.