Abstract
Background
Multiple sclerosis (MS) has both an inflammatory and a neurodegenerative component,
with gray matter (GM) atrophy being an important contributor to disability. Optical
coherence tomography (OCT) may serve as a prognostic tool for neuroaxonal health by
measuring ganglion cell inner plexiform layer (GCIPL) thickness. There is a paucity
of literature regarding the effects of race on pathobiology of MS, as racial minorities
are underrepresented in research studies.
Objective
The aim of this paper is to compare the correlation between GM fraction (GMF) and
GCIPL thickness in Caucasian Americans with MS (CAMS) and African Americans with MS
(AAMS).
Methods
Fifty-nine patients with relapsing-remitting multiple sclerosis (RRMS) were included.
Using a cross-sectional design, we compared the OCT (GCIPL thickness) and MRI (GMF)
data of 32 CAMS and 27 AAMS patients.
Results
No significant correlation was observed between GMF and GCIPL in our study group (p = 0.127, r = 0.148). CAMS exhibited a significant correlation between these measures (p = 0.0004, r = 0.434), while in AAMS these measures did not correlate significantly (p = 0.187, r = −0.201).
Conclusion
GCIPL might be a sensitive biomarker predicting GM atrophy and disability in CAMS,
but not in AAMS. Larger studies are needed to investigate reliable biomarkers across
races. Inclusion of AAMS in research studies is necessary to shed more light on the
pathobiology of MS.
Keywords
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Article info
Publication history
Published online: April 03, 2019
Accepted:
April 1,
2019
Received in revised form:
March 31,
2019
Received:
December 16,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
