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The association between dietary sugar intake and neuromyelitis optica spectrum disorder: A case–control study

  • Author Footnotes
    1 Nasim Rezaeimanesh and Soodeh Razeghi Jahromi have equally taken part.
    Nasim Rezaeimanesh
    Footnotes
    1 Nasim Rezaeimanesh and Soodeh Razeghi Jahromi have equally taken part.
    Affiliations
    Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

    Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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  • Author Footnotes
    1 Nasim Rezaeimanesh and Soodeh Razeghi Jahromi have equally taken part.
    Soodeh Razeghi Jahromi
    Footnotes
    1 Nasim Rezaeimanesh and Soodeh Razeghi Jahromi have equally taken part.
    Affiliations
    Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

    Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Zeinab Ghorbani
    Affiliations
    Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

    School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
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  • Nahid Beladi Moghadam
    Affiliations
    Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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  • Azita Hekmatdoost
    Affiliations
    Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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  • Abdorreza Naser Moghadasi
    Affiliations
    Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
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  • Amir Reza Azimi
    Affiliations
    Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
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  • Mohammad Ali Sahraian
    Correspondence
    Corresponding author.
    Affiliations
    Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
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  • Author Footnotes
    1 Nasim Rezaeimanesh and Soodeh Razeghi Jahromi have equally taken part.

      Highlights

      • The effects of high sugar intake on inflammation and dysbiosis have been noted.
      • Our result suggests a direct association between sugar intake and odds of NMOSD.
      • There was no significant correlation between sugar intake and EDSS.
      • There was no significant correlation between sugar intake and relapse rate.

      Abstract

      Background

      Neuromyelitis optica spectrum disorder (NMOSD) is an uncommon autoimmune disease of the central nerves system (CNS) by inflammatory nature. The effects of high dietary sugar intake on inflammation and dysbiosis have been received more attention in recent years. The aim of the present study was to investigate the association between various types of dietary sugar intake and NMOSD odds and clinical features.

      Method

      The current case–control study was conducted among 70 patients with definite NMOSD diagnosis based on 2015 international consensus criteria and 164 hospital-based controls. Demographic and anthropometric information in all participants and disease characteristics just in case group were obtained. Dietary data during the past year of study attendance was collected by a validated 168-item food frequency questionnaire. Participants were stratified into 3 tertiles according to each type of sugar intake and the third tertile considered as reference in multivariate regression models. The correlation between dietary sugar and disease features were analyzed using Pearson correlation test.

      Results

      The mean ± SD of total sugar intake increased from 80.73 ± 17.71 to 208.71 ± 57.93 g/day across tertiles of total sugar intake. In fully adjusted model, lower intake of sugar was associates with decreased odds of NMOSD in the first tertile vs third tertile by ORs of: 0.02(CI:0.00–0.08; p-for-trend:0.00), 0.02(CI:0.00–0.10; p-for-trend:0.00), 0.23(CI:0.08–0.61; p-for-trend:0.00), 0.19(CI:0.06–0.58; p-for-trend:0.00) and 0.16(CI:0.05–0.51; p-for-trend:0.00) for glucose, fructose, galactose, lactose and sucrose, respectively. The odds of NMOSD had a 1.72-fold (CI: 1.43–2.03; p-for-trend:0.00) significant raise per every 10 g increase for total sugar intake. There was no significant correlation between various types of dietary sugar intakes and relapse rate or patients’ disability.

      Conclusion

      The present study proposes a possible direct association between high intake of various sugar types and odds of suffering from NMOSD. More investigations are needed to prove this results.

      Keywords

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