Highlights
- •Revise highlights to: NMOSD Patients have worse quality of life in comparison to MS patients.
- •NMOSD patients can be screened for fatigue, depression, and related impaired abilities with better rehabilitation strategies Fatigue is the most important variable to predict quality of life in NMOSD patients.
- •Healthcare policymakers in Iran and other countries should make better health and welfare service policies for NMOSD patients.
Abstract
Background
Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are associated
with reduced Health Related Quality of Life (HRQOL). To the best of our knowledge,
change of HRQOL in patients with NMOSD has not been yet measure in Iran. The objective
of this study was to assess HRQOL in NMOSD and MS patients and identify related factors
Methods
A cross sectional study of 41 patients with NMOSD and 136 age and sex-match MS patients
was performed. A series of questionnaires including Persian validated questionnaires
on HRQOL (SF-36), fatigue (MFIS), depression (BDI-II), anxiety (HAM-A) and sleep quality
(PSQI) were record. All demographic variables, socioeconomic status and clinical data
were also obtained. Student's T test and Mann–Whitney U test used to compare variables between groups and multivariate regression analysis
applied to assay predictor factors.
Results
The mean scores of mental (MCS) and physical (PCS) components of QOL were statistically
lower in patients with NMOSD compare with MS patients (β = −4.49, P = 0.004; β = −3.52,
P = 0.015). Multivariate analysis indicated fatigue, depression and anxiety were independent,
significant predictor of MCS (β = −0.229, P = 0.002; β = −0.229, P = 0.002; β = −0.258,
P = 0.020 respectively). However, PCS was significantly predicted by fatigue (β = −0.258 P < 0.001),
solely.
Conclusion
These findings indicate NMOSD patients have lower HRQOL in compare to patients with
MS. Also, screening and treatment of fatigue as the most important predictor for HRQOL
is necessary.
Keywords
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Article info
Publication history
Published online: April 14, 2018
Accepted:
April 13,
2018
Received in revised form:
March 7,
2018
Received:
December 19,
2017
Identification
Copyright
© 2018 Published by Elsevier B.V.
